MDM2
MDM2 oncogene, E3 ubiquitin protein ligase
Sinonimi:
ACTFS, HDMX, hdm2
Specie:
Human MDM2 (4193), Mouse Mdm2 (17246), Rat Mdm2 (314856), Zebrafish mdm2 (30637), dog MDM2 (403693), domestic cat MDM2 (493939), cow MDM2 (540378), Horse MDM2 (100033891), chicken MDM2 (395609), domestic guinea pig Mdm2 (100724684) ...Più
ID UniProtKB:
ID gene:
- Human(4193) Summary: This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
- Mouse(17246) transformed mouse 3T3 cell double minute 2
- Rat(314856) p53 E3 ubiquitin protein ligase
- Zebrafish(30637) transformed 3T3 cell double minute 2 homolog (mouse)
- dog(403693) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- domestic cat(493939) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- cow(540378) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- Horse(100033891) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- chicken(395609) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- domestic guinea pig(100724684) MDM2 oncogene, E3 ubiquitin protein ligase
- naked mole-rat(101724821) MDM2 oncogene, E3 ubiquitin protein ligase
- sheep(101104979) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
ELISA
N° Catalogo
Descrizione
Specie
Antibodies
N° Catalogo
Descrizione
Reattività con
Applicazione
Anticorpo anti-MDM2, clone IF2, clone IF2, from mouse,
Reattività con
human
Applicazione
immunohistochemistry
western blot
western blot
Anti-MDM2 (Ab-2) Mouse mAb (2A10), liquid, clone 2A10, Calbiochem®,
Reattività con
human
Applicazione
Anti-MDM2 Antibody, clone IF2, Alexa Fluor™ 488 Conjugate, clone IF2, from mouse, ALEXA FLUOR™ 488,
Reattività con
human
Applicazione
immunocytochemistry
Anti-MDM2 Antibody, clone 2A10, clone 2A10, from mouse,
Reattività con
human
Applicazione
immunoprecipitation (IP)
western blot
western blot
Monoclonal Anti-MDM2 antibody produced in mouse, ~2 mg/mL, clone MD-219, purified immunoglobulin, buffered aqueous solution,
Reattività con
mouse
Applicazione
ELISA
flow cytometry
immunocytochemistry
microarray
western blot
flow cytometry
immunocytochemistry
microarray
western blot