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Merck

LMNA

lamin A/C

Sinonimi:
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1
Specie:
Human LMNA (4000), Mouse Lmna (16905), Rat Lmna (60374), Zebrafish lmna (195815), cow LMNA (404144), Horse LMNA (100057663), domestic cat LMNA (101086199), dog LMNA (480124), chicken LMNA (415464), domestic guinea pig Lmna (100735212) ...Più
ID UniProtKB:
P02545, B4DI32, D3DVB0, E7EUI9, P02546, Q5TCJ2, Q5TCJ3, Q969I8
ID gene:
  • Human(4000) Summary: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
  • Mouse(16905) lamin A
  • Rat(60374) lamin A/C
  • Zebrafish(195815) lamin A
  • cow(404144) lamin A/C
  • Horse(100057663) lamin A/C
  • domestic cat(101086199) lamin A/C
  • dog(480124) lamin A/C
  • chicken(415464) lamin A/C
  • domestic guinea pig(100735212) lamin A/C
  • naked mole-rat(101704567) lamin A/C
  • sheep(101107924) lamin A/C

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Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
05-1231
Anti-Progerin Antibody, clone 13A4, clone 13A4, Upstate®, from mouse,
Reattività con
human
Applicazione
ELISA
immunocytochemistry
immunoprecipitation (IP)
western blot
MABT858
Anticorpo anti-prelamina A, clone PL-1C7, clone PL-1C7, from mouse,
Reattività con
human, mouse
Applicazione
ELISA
flow cytometry
immunocytochemistry
western blot
MABT345
Anti-Prelamin-A Antibody, clone 7G11, clone 7G11, from rat,
Reattività con
mouse
Applicazione
immunofluorescence
western blot
SAB4200272
Anti-Progerin antibody, Mouse monoclonal, clone 13A4, purified from hybridoma cell culture,
Reattività con
human
Applicazione
immunofluorescence
immunoprecipitation (IP)
western blot
MABT1341
Anti-Lamin A/C Antibody, clone 4C11, clone 4C11, from mouse,
Reattività con
syrian hamster, human, monkey, mouse, rat
Applicazione
ChIP
immunofluorescence
immunoprecipitation (IP)
western blot

esiRNA

N° Catalogo
Descrizione
Specie
EMU056191
MISSION® esiRNA, targeting mouse Lmna,
Specie
mouse
EHU063791
MISSION® esiRNA, targeting human LMNA,
Specie
human