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Merck

GRM1

glutamate receptor, metabotropic 1

Sinonimi:
GPRC1A, MGLU1, MGLUR1, SCAR13
Specie:
ID UniProtKB:
ID gene:
  • Human(2911) Summary: This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
  • Mouse(14816) glutamate receptor, metabotropic 1
  • Rat(24414) glutamate receptor, metabotropic 1
  • domestic guinea pig(100730891) glutamate receptor, metabotropic 1
  • naked mole-rat(101712477) glutamate receptor, metabotropic 1
  • Domestic Rabbit(100356201) glutamate receptor, metabotropic 1
  • Zebrafish(100150246) glutamate receptor, metabotropic 1
  • dog(484024) glutamate receptor, metabotropic 1
  • domestic cat(101094104) glutamate receptor, metabotropic 1
  • cow(540485) glutamate receptor, metabotropic 1
  • Horse(100060603) glutamate receptor, metabotropic 1
  • chicken(421614) glutamate receptor, metabotropic 1

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Small Molecule - Agonist

N° Catalogo
Descrizione
Specie
(S)-3,5-Dihydroxyphenylglycine hydrate, ≥98% (HPLC), powder,
Specie
human
Ibotenic acid, ~95%, solid,
Specie
rat
D-2-Aminoadipic acid, ,
Specie
rat
L-2-Aminoadipic acid, ≥98% (TLC),
Specie
rat, human
Quisqualic acid, powder,
Specie
rat

Small Molecule - Antagonist

N° Catalogo
Descrizione
Specie
(+)-α-Methyl-4-carboxyphenylglycine, solid,
Specie
rat
SIB 1757, ≥99% (HPLC), crystalline,
Specie
human
AIDA, solid,
Specie
rat, human
SIB 1893, >99%, solid,
Specie
human
D-2-Aminoadipic acid, ,
Specie
rat

Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
Monoclonal Anti-Glutamate antibody produced in mouse, clone GLU-4, ascites fluid,
Reattività con
wide range
Applicazione
ELISA
Anti-GRM1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunohistochemistry
Anti-Metabotropic Glutamate Receptor 1α Antibody, pain, CT, Chemicon®, from rabbit,
Reattività con
human, monkey, rat
Applicazione
immunohistochemistry
western blot
Anti-Metabotropic Glutamate Receptor 1 Antibody, Chemicon®, from rabbit,
Reattività con
human
Applicazione
immunohistochemistry
Anticorpo anti-mGluR1, Upstate®, from rabbit,
Reattività con
rat
Applicazione
western blot

Small Molecule - Inhibitor

N° Catalogo
Descrizione
Specie
L-2-Aminoadipic acid, ≥98% (TLC),
Specie
rat, human
Quisqualic acid, powder,
Specie
rat
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Specie
rat, human
(Aminomethyl)phosphonic acid, 99%,
Specie
rat, human
Acido L-glutammico, ReagentPlus®, ≥99% (HPLC),
Specie
rat, human

Small Molecule - Mixed Agonist/Antagonist

N° Catalogo
Descrizione
Specie
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Specie
rat, human
(±)-AMPA, solid,
Specie
rat
Acido L-glutammico, ReagentPlus®, ≥99% (HPLC),
Specie
rat, human
Acido L-glutammico, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
Specie
rat, human
Acido L-glutammico, BioUltra, ≥99.5% (NT),
Specie
rat, human

esiRNA

N° Catalogo
Descrizione
Specie
MISSION® esiRNA, targeting mouse Grm1,
Specie
mouse
MISSION® esiRNA, targeting human GRM1,
Specie
human