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Merck

DLAT

dihydrolipoamide S-acetyltransferase

Sinonimi:
DLTA, PDC-E2, PDCE2
Specie:
Human DLAT (1737), Mouse Dlat (235339), Rat Dlat (81654), Zebrafish dlat (324201), domestic cat DLAT (101094126), cow DLAT (512723), Horse DLAT (100062027), dog DLAT (489406), chicken DLAT (419796), naked mole-rat Dlat (101698667) ...Più
ID UniProtKB:
P10515, Q16783, Q53EP3
ID gene:
  • Human(1737) Summary: This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.[provided by RefSeq, Oct 2009]
  • Mouse(235339) dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
  • Rat(81654) dihydrolipoamide S-acetyltransferase
  • Zebrafish(324201) dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
  • domestic cat(101094126) dihydrolipoamide S-acetyltransferase
  • cow(512723) dihydrolipoamide S-acetyltransferase
  • Horse(100062027) dihydrolipoamide S-acetyltransferase
  • dog(489406) dihydrolipoamide S-acetyltransferase
  • chicken(419796) dihydrolipoamide S-acetyltransferase
  • naked mole-rat(101698667) dihydrolipoamide S-acetyltransferase
  • domestic guinea pig(100735563) dihydrolipoamide S-acetyltransferase
  • sheep(101110965) dihydrolipoamide S-acetyltransferase
  • Domestic Rabbit(100349212) dihydrolipoamide S-acetyltransferase

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Antibodies

Product Number
Descrizione
Reattività con
Applicazione
SAB5702646
Anti-DLAT Antibody, clone 2Z7R10, Rabbit Monoclonal, ,
Reattività con
human, rat
Applicazione
western blot
AV41994
Anti-DLAT antibody produced in rabbit, IgG fraction of antiserum,
Reattività con
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Applicazione
immunohistochemistry
western blot
HPA040786
Anti-DLAT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunofluorescence
immunohistochemistry
western blot
SAB1410301
Anti-DLAT antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Reattività con
human
Applicazione
immunofluorescence
western blot
HPA062766
Anti-DLAT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reattività con
human
Applicazione
immunofluorescence
western blot

esiRNA

Product Number
Descrizione
Specie
EHU029881
MISSION® esiRNA, targeting human DLAT,
Specie
human