BRCA1
breast cancer 1, early onset
Sinonimi:
BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53
Specie:
Human BRCA1 (672), Mouse Brca1 (12189), Rat Brca1 (497672), Thale Cress BRCA1 (827854), domestic cat BRCA1 (493761), cow BRCA1 (353120), Horse BRCA1 (100051990), domestic cat BRCA1 (101081937), dog BRCA1 (403437), chicken BRCA1 (373983) ...Più
ID UniProtKB:
ID gene:
- Human(672) Summary: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009]
- Mouse(12189) breast cancer 1
- Rat(497672) breast cancer 1, early onset
- Thale Cress(827854) protein BREAST CANCER SUSCEPTIBILITY 1-like protein
- domestic cat(493761) breast cancer 1, early onset
- cow(353120) breast cancer 1, early onset
- Horse(100051990) breast cancer 1, early onset
- domestic cat(101081937) breast cancer 1, early onset
- dog(403437) breast cancer 1, early onset
- chicken(373983) breast cancer 1, early onset
- naked mole-rat(101705460) breast cancer 1, early onset
- domestic guinea pig(100722339) breast cancer 1, early onset
- sheep(101108584) breast cancer 1, early onset
- Domestic Rabbit(100347269) breast cancer 1, early onset
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Antibodies
N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-BRCA1 (Ab-1) Mouse mAb (MS110), liquid, clone MS110, Calbiochem®,
Reattività con
human
Applicazione
Anticorpo anti-BRCA1, serum, Upstate®,
Reattività con
human
Applicazione
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Monoclonal Anti-BRCA1 antibody produced in mouse, ,
Reattività con
human, mouse
Applicazione
ChIP
immunocytochemistry
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
immunocytochemistry
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-BRCA1 Antibody, clone 2C15 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reattività con
human, mouse
Applicazione
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-BRCA1 Antibody, clone MS110, clone MS110, from mouse,
Reattività con
human
Applicazione
immunocytochemistry
western blot
western blot
Kits
N° Catalogo
Descrizione
Specie
CpG WIZ™ BRCA1 -Methylation specific PCR assay, Methylation-specific PCR (MSP), performed using the CpGenome DNA Modification Kit & the CpG WIZ BRCA1 Amplification Kit, permits sensitive detection of altered DNA.,
Specie
human