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Merck

ATXN1

ataxin 1

Sinonimi:
ATX1, D6S504E, SCA1
Specie:
ID UniProtKB:
ID gene:
  • Human(6310) Summary: The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2010]
  • Mouse(20238) ataxin 1
  • Rat(25049) ataxin 1
  • chicken(420843) ataxin 1
  • cow(616399) ataxin 1
  • Horse(100065748) ataxin 1
  • domestic cat(493678) ataxin 1
  • domestic cat(101092517) ataxin 1
  • dog(488232) ataxin 1
  • naked mole-rat(101710194) ataxin 1
  • domestic guinea pig(100719683) ataxin 1
  • sheep(101113284) ataxin 1

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Antibodies

Product Number
Descrizione
Reattività con
Applicazione
Anti-Ataxin-1 Antibody, 11NQ, clone N76/8, clone N76/8, from mouse,
Reattività con
mouse, rat
Applicazione
immunohistochemistry
Anti-Ataxin 1, C-Terminal antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse
Applicazione
ELISA
immunofluorescence

immunohistochemistry
Monoclonal Anti-Ataxin 1 antibody produced in mouse, clone S76-8, purified immunoglobulin,
Reattività con
human, mouse, rat
Applicazione
immunohistochemistry
immunoprecipitation (IP)

western blot
Anti-ATXN1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunohistochemistry
Anti-ATXN1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reattività con
human
Applicazione
immunofluorescence

esiRNA

Product Number
Descrizione
Specie
MISSION® esiRNA, targeting mouse Atxn1,
Specie
mouse
MISSION® esiRNA, targeting human ATXN1 (1),
Specie
human
MISSION® esiRNA, targeting human ATXN1 (2),
Specie
human