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N183

Sigma-Aldrich

NBQX disodium salt hydrate

≥98% (HPLC), lyophilized powder, neuroprotective AMPA/kainate glutamate receptor antagonist

Synonym(s):

1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide disodium salt hydrate, FG 9202 disodium salt hydrate

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$459.00
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$1,750.00

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5 MG
$459.00
25 MG
$1,750.00

About This Item

Empirical Formula (Hill Notation):
C12H6N4Na2O6S · xH2O
CAS Number:
118876-58-7
Molecular Weight:
380.24 (anhydrous basis)
MDL number:
MFCD12910445
UNSPSC Code:
12352200
PubChem Substance ID:
24277996
NACRES:
NA.77

$459.00

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Product Name

NBQX disodium salt hydrate, ≥98% (HPLC)

Quality Level

100

Assay

≥98% (HPLC)

form

lyophilized powder

storage condition

desiccated

color

, brown to dark red-brown

solubility

H2O: >10 mg/mL

storage temp.

2-8°C

SMILES string

O.[Na+].[Na+].NS(=O)(=O)c1cccc2c1c(cc3nc([O-])c([O-])nc23)[N+]([O-])=O

InChI

1S/C12H8N4O6S.2Na.H2O/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6;;;/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22);;;1H2/q;2*+1;/p-2

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NBQX hydrate

form

lyophilized powder

form

powder

form

solid

form

powder

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

-

solubility

H2O: >10 mg/mL

solubility

-

solubility

H2O: >2 mg/mL (warmed)

solubility

methanol: 0.25 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.5 mg/mL, DMSO: 4 mg/mL, H2O: insoluble

storage condition

desiccated

storage condition

-

storage condition

protect from light

storage condition

-

Application

NBQX disodium salt hydrate has been used:
  • in N-methyl-D-aspartate receptor (NMDAR) kinetic studies[1]
  • as an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist for the electrophysiological studies cultured neurons[2]
  • in the extracellular solution for current/voltage (I/V) relationship and rectification index experiments in excitatory postsynaptic currents (EPSCs) mediated by NMDA receptors (EPSCNMDAR)[3]

Biochem/physiol Actions

NBQX disodium salt hydrate is a neuroprotective AMPA/kainate glutamate receptor antagonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Certificates of Analysis (COA)

    Lot/Batch Number
    027M4608V
    092M4622V
    062M4623V
    012M4626V
    068K46044V

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    Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology
    Bardy C, et al.
    Molecular Psychiatry, 21(11), 1573-1573 (2016)
    Cross-modal reinstatement of thalamocortical plasticity accelerates ocular dominance plasticity in adult mice
    Rodriguez G, et al.
    Cell Reports, 24(13), 3433-3440 (2018)
    The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning
    Zhou Z, et al.
    Nature Neuroscience, 21(1), 50-50 (2018)
    Sandra Jurado et al.
    Neuron, 77(3), 542-558 (2013-02-12)
    Membrane fusion during exocytosis is mediated by assemblies of SNARE (soluble NSF-attachment protein receptor) and SM (Sec1/Munc18-like) proteins. The SNARE/SM proteins involved in vesicle fusion during neurotransmitter release are well understood, whereas little is known about the protein machinery that
    Amy M Pooler et al.
    EMBO reports, 14(4), 389-394 (2013-02-16)
    Propagation of tau pathology is linked with progressive neurodegeneration, but the mechanism underlying trans-synaptic spread of tau is unknown. We show that stimulation of neuronal activity, or AMPA receptor activation, induces tau release from healthy, mature cortical neurons. Notably, phosphorylation
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