422711-M

KN-93, Water-Soluble

This KN-93 is a water-soluble version of KN-93 that acts as a reversible and competitive inhibitor of CaM kinase II (K_i = 370 nM for rat brain).

• Synonym(s): KN-93, Water-Soluble
• Empirical Formula (Hill Notation): C₂₆H₂₉ClN₂O₄S · xH₃PO₄
• Molecular Weight: 501.04
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: white
• solubility: water: 5 mg/mL
• storage temp.: 2-8°C

Description

General description

Also available as a 5 mM solution in H₂O(Cat. No. 508315).

A water-soluble form of the CaM kinase II inhibitor KN-93 (Cat. No. 422708. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Has no significant effect on protein kinase A activity. Induces G₁ cell cycle arrest and apoptosis in NIH 3T3 cells.

Biochem/physiol Actions

Primary Target
Calmodulin-Dependent Protein Kinase (CaM Kinase) 2

Target K_i: 370 nM for cam kinase 2

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Tombes, R.M., et al. 1995. Cell Growth Differ.6, 1063.
Chen, C., et al. 1994. Science266, 291.
Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun.195, 608.
Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun.191, 255.
Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun.181, 968.
Tokumitsu, H., et al. 1990. J. Biol. Chem.265, 4315.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable