Comparison of the pharmacokinetics between L-BPA and L-FBPA using the same administration dose and protocol: a validation study for the theranostic approach using [

Boron neutron capture therapy (BNCT) is a cellular-level particle radiation therapy that combines the selective delivery of boron compounds to tumour tissue with neutron irradiation. L-p-Boronophenylalanine (L-BPA) is a boron compound now widely used in clinical situations. Determination of the boron distribution is required for successful BNCT prior to neutron irradiation. Thus, positron emission tomography with [ SCC-VII was subcutaneously inoculated into the legs of C3H/He mice. The same dose of L-BPA or [ There were no differences between L-BPA and [ No difference was noted in the time course of the boron concentrations in tumour tissue and normal tissues between L-BPA and [