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  • 1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: application in the synthesis of potent human melanocortin-4 receptor selective agonists.

1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: application in the synthesis of potent human melanocortin-4 receptor selective agonists.

Bioorganic & medicinal chemistry letters (2005-06-14)
Raman K Bakshi, Qingmei Hong, J T Olson, Zhixiong Ye, Iyassue K Sebhat, David H Weinberg, Tanya MacNeil, Rubana N Kalyani, Rui Tang, William J Martin, Alison Strack, Erin McGowan, Constantin Tamvakopoulos, Randy R Miller, Ralph A Stearns, Wei Tang, D Euan Maclntyre, Lex H T van der Ploeg, Arthur A Patchett, Ravi P Nargund
PMID15951175
ABSTRACT

The discovery of 1-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid analogs as potent human melanocortin-4 selective agonists is described.

MATERIALS
Product Number
Brand
Product Description
214930
Sigma-Aldrich
1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid hydrochloride, 96%
421626
Sigma-Aldrich
(S)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid, 97%