Skip to Content
Merck
  • Disterolphospholipids: nonexchangeable lipids and their application to liposomal drug delivery.

Disterolphospholipids: nonexchangeable lipids and their application to liposomal drug delivery.

Angewandte Chemie (International ed. in English) (2009-05-09)
Zhaohua Huang, Mahmoud Reza Jaafari, Francis C Szoka
ABSTRACT

Extreme makeover of cholesterol: Cholesterol exchange is a major reason for the instability of liposomes in blood. The formation of a covalent hybrid between cholesterol and glycerophosphocholine preserves the bilayer-stabilizing effect of free cholesterol but prevents its transfer from the bilayer. Thus, disterolphospholipids (e.g. 1) are valuable new components for liposome formulation.

MATERIALS
Product Number
Brand
Product Description

Avanti
DChemsPC, Avanti Research - A Croda Brand 880346P, powder
Avanti
PChemsPC, Avanti Research - A Croda Brand 880343P, powder
Avanti
OChemsPC, Avanti Research - A Croda Brand 880344P, powder
Avanti
PChcPC, Avanti Research - A Croda Brand 880345P, powder