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Merck

NEFL

neurofilament, light polypeptide

Synonyms:
CMT1F, CMT2E, NF-L, NF68, NFL
Species:
UniProtKB ID:
Gene ID:
  • Human(4747) Summary: Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008]
  • Mouse(18039) neurofilament, light polypeptide
  • Rat(83613) neurofilament, light polypeptide
  • chicken(419528) neurofilament, light polypeptide
  • cow(281348) neurofilament, light polypeptide
  • domestic cat(101081039) neurofilament, light polypeptide
  • dog(477378) neurofilament, light polypeptide
  • naked mole-rat(101704332) neurofilament, light polypeptide
  • domestic guinea pig(100731797) neurofilament, light polypeptide
  • sheep(101119539) neurofilament, light polypeptide

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-Neurofilament 68 antibody produced in mouse, clone NR4, ascites fluid,
Species Reactivity
chicken, human, pig, rat
Application
immunohistochemistry
microarray

western blot
Anti-Neurofilament L Antibody, clone 1E13 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human
Application
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Neurofilament Antibodies Investigator Antibody Mini-Pack, anti-neurofilament H&M antibody, anti-neurofilament H antibody, and anti-neurofilament L antibody,
Species Reactivity
Application
Anti-Neurofilament L Antibody, serum, Chemicon®,
Species Reactivity
bovine, canine, feline, human, mouse, pig, rat
Application
immunocytochemistry
immunohistochemistry

western blot
Anti-NEFL antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human NEFL,
Species
human