- Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release.
Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release.
Proceedings of the National Academy of Sciences of the United States of America (2017-03-08)
Chuchu Zhang, Katalin F Medzihradszky, Elda E Sánchez, Allan I Basbaum, David Julius
PMID28265084
ABSTRACT
Pain-producing animal venoms contain evolutionarily honed toxins that can be exploited to study and manipulate somatosensory and nociceptive signaling pathways. From a functional screen, we have identified a secreted phospholipase A2 (sPLA2)-like protein, BomoTx, from the Brazilian lancehead pit viper (
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Protease from Streptomyces griseus, powder, BioReagent, suitable for mouse embryo cell culture, ≥3.5 units/mg solid
Sigma-Aldrich
ProteoMass™ ACTH Fragment 18-39 MALDI-MS Standard, vial of 10 nmol, monoisotopic mol wt 2,464.1989 Da
Sigma-Aldrich
ProteoMass™ Insulin MALDI-MS Standard, vial of 10 nmol, monoisotopic mol wt 5,729.6087 Da
Sigma-Aldrich
ProteoMass™ Cytochrome c MALDI-MS Standard, vial of 10 nmol, (M+H+) 12,361.96 Da by calculation
Sigma-Aldrich
ProteoMass™ Apomyoglobin MALDI-MS Standard, vial of 10 nmol, (M+H+) 16,952.27 Da by calculation