- Bioinspired, releasable quorum sensing modulators.
Bioinspired, releasable quorum sensing modulators.
Chemical communications (Cambridge, England) (2012-11-22)
José Gomes, Alexander Grunau, Adrien K Lawrence, Leo Eberl, Karl Gademann
PMID23169441
ABSTRACT
We demonstrate the synthesis and immobilization of natural product hybrids featuring an acyl-homoserine lactone and a nitrodopamine onto biocompatible TiO(2) surfaces through an operationally simple dip-and-rinse procedure. The resulting immobilized hybrids were shown to be powerful quorum sensing (QS) activators in Pseudomonas strains acting by slow release from the surface.
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