T6277
Monoclonal Anti-Troponin T antibody produced in mouse
clone JLT-12, ascites fluid
Synonym(s):
Anti-ANM, Anti-NEM5, Anti-STNT, Anti-TNT, Anti-TNTS
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About This Item
Recommended Products
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
JLT-12, monoclonal
contains
15 mM sodium azide
species reactivity
chicken, rat, bovine, rabbit
technique(s)
immunohistochemistry: suitable
western blot: 1:200 using rabbit total skeletal muscle extract
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
rat ... Tnnt1(171409) , Tnnt2(24837) , Tnnt3(24838)
General description
Monoclonal Anti-Troponin T (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.
Troponin T is a vital subunit of troponin. Troponin T is a comma or rod shaped protein with a length of 185-205 Å. Troponin T is positioned in the actin helix groove and is extended along the filament of troponin. Life span of serum troponin T is 120 minutes. N- terminal end of the protein is enriched in negatively charged residues and C- terminal end is enriched with positively charged residues. This uneven distribution of charges in troponin T facilitates its aggregation at physiological salt concentration. In humans, cardiac troponin T exists in four isoforms, out of which three are expressed in the fetus and one isoform is expressed in the adult heart.
Immunogen
Troponin T from rabbit skeletal muscle.
Application
Monoclonal Anti-Troponin T antibody produced in mouse has been used in following studies:
- Western blot analysis.
- Immunocytochemical analysis.
- Immunofluorescence.
Monoclonal Anti-Troponin T antibody produced in mouse has been used in immunostaining.
Biochem/physiol Actions
Troponin T is a subunit of troponin, which facilitates binding of troponin to tropomyosin. It also plays a crucial role in muscle contraction. Cardiac troponin T acts as a potential marker for the detection of acute myocardial infarction (MI). Apart from facilitating binding of troponin components to the actin-tropomyosin filament, it is has an essential role in the regulation of actomyosin ATPase activity. Cardiac troponin T gene mutation leads to hypertrophic cardiomyopathy.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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This review discusses the structure and properties of the isolated components of troponin, their interaction, and the mechanisms of regulation of contractile activity of skeletal and cardiac muscle. Data on the structure of troponin C in crystals and in solution
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