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P5386

Sigma-Aldrich

Poly-γ-benzyl-L-glutamate

mol wt 70,000-150,000

Synonym(s):

PBLG

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About This Item

CAS Number:
25014-27-1
MDL number:
MFCD00166357
UNSPSC Code:
12352202
NACRES:
NA.26

form

powder

mol wt

70,000-150,000

color

white to light yellow

storage temp.

−20°C

InChI

1S/C12H15NO4/c13-10(12(15)16)6-7-11(14)17-8-9-4-2-1-3-5-9/h1-5,10H,6-8,13H2,(H,15,16)/t10-/m0/s1

InChI key

BGGHCRNCRWQABU-JTQLQIEISA-N

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Application


  • Hydrogen bond formation may enhance RDC-based discrimination of enantiomers.: This research explores the impact of hydrogen bond formation on residual dipolar couplings (RDC) in the discrimination of enantiomers. Poly-y-benzyl-L-glutamate (PBLG) is used as a chiral alignment medium, enhancing the sensitivity and resolution of NMR spectroscopy for enantiomeric analysis (Sager et al., 2024).

  • Potential and performance of anisotropic (19)F NMR for the enantiomeric analysis of fluorinated chiral active pharmaceutical ingredients.: This study highlights the use of PBLG as an alignment medium in anisotropic 19F NMR spectroscopy for analyzing chiral pharmaceutical compounds. The research demonstrates improved enantiomeric discrimination and quantification, crucial for pharmaceutical development (Gouilleux et al., 2024).

  • Block Sequence Effects on the Self-Assembly Behaviors of Polypeptide-Based Penta-Block Copolymer Hydrogels.: This study investigates the self-assembly behavior of block copolymer hydrogels containing PBLG. The research shows how block sequence affects the mechanical properties and potential applications of these hydrogels in biomedical fields (Wang et al., 2024).

  • Liquid crystalline composite hydrogels with large pH-triggered anisotropic swelling for embolotherapy.: This research explores the development of liquid crystalline hydrogels incorporating PBLG for use in embolotherapy. The hydrogels demonstrate significant pH-responsive swelling, making them suitable for targeted medical applications (Zhang et al., 2024).

Analysis Note

Molecular weight based on viscosity.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Electrospun Poly(γ-Benzyl-l-Glutamate) and Its Alkali-Treated Meshes: Their Water Wettability and Cell-Adhesion Potential.
Hakamada Y, Ohgushi N, et al.
Journal of Biomaterials Science. Polymer Edition, 28(1), 757-765 (2011)
Hua Yu Tian et al.
Biomaterials, 26(20), 4209-4217 (2005-02-03)
A novel amphiphilic biodegradable cationic hyperbranched poly(ethylene glycol)-polyethylenimine-poly(gamma-benzyl L-glutamate) (PEG-PEI-PBLG) block copolymer was successfully synthesized by ring-opening polymerization (ROP) of N-carboxyanhydride of gamma-benzyl-L-glutamate (BLG-NCA) with PEG-PEI as a macroinitiator. PEG-PEI was firstly prepared by coupling of PEG and PEI using
Permanent polarity and piezoelectricity of electrospun α-helical poly(α-amino acid) fibers.
Dawnielle Farrar et al.
Advanced materials (Deerfield Beach, Fla.), 23(34), 3954-3958 (2011-07-29)
Thavasyappan Thambi et al.
Bioconjugate chemistry, 22(10), 1924-1931 (2011-09-09)
Poly(ethylene glycol)-b-poly(γ-benzyl L-glutamate)s bearing the disulfide bond (PEG-SS-PBLGs), which is specifically cleavable in intracellular compartments, were prepared via a facile synthetic route as a potential carrier of camptothecin (CPT). Diblock copolymers with different lengths of PBLG were synthesized by ring-opening
Supramolecular triblock copolymers controlled by the coiled-coil motif: a new tool for drug delivery.
Hana Robson Marsden et al.
Journal of controlled release : official journal of the Controlled Release Society, 148(1), e110-e111 (2011-05-03)
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Articles

Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

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