466R-1

SDHB (EP288) Rabbit Monoclonal Primary Antibody

• Synonym(s): Succinate dehydrogenase B
• UNSPSC Code: 12352203

Properties

• biological source: rabbit
• Quality Level: 100; 500
• conjugate: unconjugated
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: EP288, monoclonal
• description: For In Vitro Diagnostic Use in Select Regions
• form: buffered aqueous solution
• species reactivity: human
• packaging: vial of 0.1 mL concentrate (466R-14); vial of 0.1 mL concentrate Research Use Only (466R-14-RUO); vial of 0.5 mL concentrate (466R-15); vial of 1.0 mL concentrate (466R-16); vial of 1.0 mL concentrate Research Use Only (466R-16-RUO); vial of 1.0 mL pre-dilute Research Use Only (466R-17-RUO); vial of 1.0 mL pre-dilute ready-to-use (466R-17); vial of 7.0 mL pre-dilute ready-to-use (466R-18); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (466R-18-RUO)
• manufacturer/tradename: Cell Marque^™
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)
• isotype: IgG
• control: GIST
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: cytoplasmic
• Gene Information: human ... SDHB(6390)

Description

General description

Succinate dehydrogenase B (SDHB) is an iron-sulfur subunit of mitochondrial complex II, a respiratory complex that catalyzes the oxidation of succinate in the mitochondrial membrane. Many cancers are generally positive for SDHB, including renal cell carcinomas (RCC) and gastrointestinal stromal tumors (GIST). However, a subset of RCC and GIST tumors that are associated with SDH mutations, Carney-Stratakis Syndrome or Carney Triad exhibit a loss of SDHB expression.

Quality

IVD

IVD

IVD

RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

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Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable