1.05360

L-Leucine

for biochemistry

• Synonym(s): L-Leucine, Leu
• Empirical Formula (Hill Notation): C₆H₁₃NO₂
• CAS Number: 61-90-5
• Molecular Weight: 131.17
• MDL number: MFCD00002617
• UNSPSC Code: 12352209
• EC Index Number: 200-522-0
• NACRES: NA.21

Properties

• vapor pressure: <1 hPa ( 20 °C)
• Quality Level: 100
• pH: 5.5-6.5 (20 °C, 20 g/L in H₂O)
• mp: 270-340 °C (decomposition)
• solubility: 18.9 g/L
• density: 1.17 g/cm³ at 20 °C
• bulk density: 300‑400 kg/m³
• storage temp.: 2-30°C
• InChI: 1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)
• InChI key: ROHFNLRQFUQHCH-UHFFFAOYSA-N

Description

Application

• Novel recombinant aminoacylase from Paraburkholderia monticola capable of N-acyl-amino acid synthesis.: Highlights the synthetic application of L-Leucine in producing N-acyl-amino acids using engineered enzymes, showcasing its industrial and biotechnological potential (Haeger et al., 2024).

Analysis Note

Assay (perchloric acid titration, calculated on dried substance): ≥ 99.0 %
Identity (IR-spectrum): passes test
Appearance: white to almost white, crystalline powder or shiny flakes
Appearance of solution (0.5 mol/l, hydrochloric acid 1 mol/l): clear and colorless
Spec. rotation (α 20/D, 50 g/l, hydrochloric acid 1 mol/l, calc. on dried substance): +12.2 to +13.2
UV-Absorption (260 nm, 0.5 mol/l, 1 cm, hydrochloric acid 1 mol/l): ≤ 0.05
UV-Absorption (280 nm, 0.5 mol/l, 1 cm, hydrochloric acid 1 mol/l): ≤ 0.02
Chloride (Cl): ≤ 0.02 %
Sulfate (SO₄): ≤ 0.01 %
Heavy metals (as Pb): ≤ 0.001 %
As (Arsenic): ≤ 0.0005 %
Ca (Calcium): ≤ 0.001 %
Co (Cobalt): ≤ 0.0005 %
Fe (Iron): ≤ 0.0005 %
K (Potassium): ≤ 0.0005 %
Mg (Magnesium): ≤ 0.0005 %
Na (Sodium): ≤ 0.005 %
Zn (Zinc): ≤ 0.0005 %
NH₄ (Ammonium): ≤ 0.01 %
Isoleucine: ≤ 1.0 %
other foreign amino acids: ≤ 0.3 %
Other ninhydrine positive substances: ≤ 0.1 %
Loss on drying (105 °C; 3 h): ≤ 0.3 %

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1