PDE4A
phosphodiesterase 4A, cAMP-specific
Synonyms:
DPDE2, PDE4, PDE46
Species:
Human PDE4A (5141), Mouse Pde4a (18577), Rat Pde4a (25638), Zebrafish pde4a (572061), chicken PDE4A (769860), dog PDE4A (100683695), domestic cat PDE4A (751107), cow PDE4A (512222), sheep PDE4A (101117505), domestic guinea pig Pde4a (100135594) ...More
UniProtKB ID:
Gene ID:
- Human(5141) Summary: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
- Mouse(18577) phosphodiesterase 4A, cAMP specific
- Rat(25638) phosphodiesterase 4A, cAMP-specific
- Zebrafish(572061) phosphodiesterase 4A, cAMP-specific
- chicken(769860) phosphodiesterase 4A, cAMP-specific
- dog(100683695) phosphodiesterase 4A, cAMP-specific
- domestic cat(751107) phosphodiesterase 4A, cAMP-specific
- cow(512222) phosphodiesterase 4A, cAMP-specific
- sheep(101117505) phosphodiesterase 4A, cAMP-specific
- domestic guinea pig(100135594) phosphodiesterase 4A, cAMP-specific
- naked mole-rat(101717168) phosphodiesterase 4A, cAMP-specific
- Domestic Rabbit(100009247) phosphodiesterase 4A, cAMP-specific
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Small Molecule - Activator
Product Number
Description
Species
Small Molecule - Antagonist
Product Number
Description
Species
Theophylline, certified reference material, United States Pharmacopeia (USP) Reference Standard,
Species
human
Theophylline melting point standard, United States Pharmacopeia (USP) Reference Standard,
Species
human
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PDE4A antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-PDE4A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-PDE4A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Small Molecule - Inhibitor
Proteins
Product Number
Description
Species
PDE4A4B active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥40% (SDS-PAGE),
Species
human
PDE4A10 active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥75% (SDS-PAGE),
Species
human
PDE4A1A Active human, recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE),
Species
human