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Merck

LDLR

low density lipoprotein receptor

Synonyms:
FH, FHC, LDLCQ2
Species:
UniProtKB ID:
Gene ID:
  • Human(3949) Summary: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
  • Mouse(16835) low density lipoprotein receptor
  • Rat(300438) low density lipoprotein receptor
  • Zebrafish(387529) low density lipoprotein receptor
  • dog(100683160) low density lipoprotein receptor
  • chicken(395103) low density lipoprotein receptor
  • domestic cat(101080362) low density lipoprotein receptor
  • cow(281276) low density lipoprotein receptor
  • Domestic Rabbit(100009086) low density lipoprotein receptor
  • domestic guinea pig(100724238) low density lipoprotein receptor
  • naked mole-rat(101703463) low density lipoprotein receptor

Custom & Knockdown Gene Products

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ELISA

Product Number
Description
Species
Human LDLR / Low-density Lipoprotein Receptor ELISA Kit, ,
Species
human
Rhesus Macaque LDL Reptor ELISA, for serum, plasma and cell culture supernatants,
Species

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-LDLR antibody produced in rabbit, Ab1, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-LDLR antibody produced in chicken, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-LDL-R antibody produced in chicken, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-LDL Receptor Antibody, clone 2N19, ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, rat
Application
flow cytometry
immunocytochemistry

immunohistochemistry

western blot
Anti-Low Density Lipoprotein Antibody, copper oxidized, serum, Chemicon®,
Species Reactivity
human
Application
ELISA
immunohistochemistry

western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human LDLR,
Species
human
MISSION® esiRNA, targeting mouse Ldlr,
Species
mouse