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Merck

KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

Synonyms:
C-Kit, CD117, PBT, SCFR
Species:
UniProtKB ID:
Gene ID:
  • Human(3815) Summary: This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(16590) kit oncogene
  • Rat(64030) v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • chicken(378783) v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • domestic cat(493766) v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • cow(280832) v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • Horse(100009704) v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • dog(403811) v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • Goat(100861386) v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • sheep(780504) v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • Domestic Rabbit(100327263) v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • domestic guinea pig(100726397) v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • naked mole-rat(101726400) v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

Custom & Knockdown Gene Products

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ELISA

Product Number
Description
Species
Phosphotyrosine KIT / Mast/stem Cell Growth Factor Receptor Kit ELISA Kit, ,
Species
human
Human KIT / Mast/Stem Cell Growth Factor Receptor Kit ELISA Kit, ,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
ANTI-C-KIT(N-TERMINAL) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, rat
Application
flow cytometry
immunohistochemistry

western blot
Monoclonal Anti-KIT antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL1657, purified immunoglobulin, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-c-Kit/CD117 Antibody, clone 1I8 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human
Application
affinity binding assay
immunohistochemistry

western blot
Anti-CD117 (c-Kit) Antibody, clone 2C11, clone 2C11, from mouse,
Species Reactivity
human, mouse
Application
flow cytometry
western blot
Anti-CD117 (c-Kit) Antibody (mouse), PE, clone ACK2, clone ACK2, 0.2 mg/mL, from rat,
Species Reactivity
mouse
Application
flow cytometry
immunocytochemistry

immunohistochemistry

Small Molecule - Inhibitor

Product Number
Description
Species
Imatinib, ,
Species
human
Pazopanib, ,
Species
human
Dasatinib, ≥98% (HPLC),
Species
human
Dasatinib, ,
Species
human

Proteins

Product Number
Description
Species
c-Kit (V560G) Protein, active, 10 µg, Active, N-terminal GST tagged recombinant human c-Kit, amino acids 544 -end, containing the V560G mutation, found in patients with gastrointestinal stromal tumours. For use in Kinase Assays.,
Species
human
c-Kit (D816V) Protein, active, 10 µg, Active, N-terminal GST tagged, recombinant human c-Kit, amino acids 544-end containing the D816V mutation, for use in Kinase Assays.,
Species
human
c-KIT (T670E), active, GST tagged human, PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
c-KIT (D820E), active, GST tagged human, PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
c-KIT (T670I), active, GST tagged human, PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human KIT,
Species
human
MISSION® esiRNA, targeting mouse Kit,
Species
mouse