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T7875

Sigma-Aldrich

Thiourea

ReagentPlus®, ≥99.0%

Synonym(s):

Sulfourea, Thiocarbamide

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About This Item

Linear Formula:
NH2CSNH2
CAS Number:
62-56-6
Molecular Weight:
76.12
Beilstein:
605327
EC Number:
200-543-5
MDL number:
MFCD00008067
UNSPSC Code:
12352100
PubChem Substance ID:
57654702
NACRES:
NA.21

Quality Level

200

product line

ReagentPlus®

Assay

≥99.0%

mp

170-176 °C (lit.)

functional group

amine
thiourea

SMILES string

NC(N)=S

InChI

1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)

InChI key

UMGDCJDMYOKAJW-UHFFFAOYSA-N

Gene Information

mouse ... Ephx2(13850)

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General description

Thiourea is an analogue of urea, containing sulphur.

Application

Thiourea has been used:
  • as a component in ice cold sample buffer for protein analysis
  • in intracellular extraction buffer for the extraction of soluble intracellular proteins
  • as a component of electrophoresis buffer

Chaotropic agent; strong denaturant. Increases solubility and recovery of proteins

Biochem/physiol Actions

Thiourea is a free radical scavenger of the peroxide radical. It was shown to inhibit lipid peroxidation and ultraviolet (UV)-induced crosslinking of collagen. Bud dormancy in plants can be inhibited by thiourea, which is used as a growth stimulator. It is also known to be used in the treatment of hyperthyroidism.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Warning

Hazard Statements

H302,H351,H361fd,H411

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 2 - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCQ0981
WXBD4589V
MKCM9946
MKCL8833
MKCK2336

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Feline hypertrophic cardiomyopathy associated with the p. A31P Mutation in cMyBP-C is caused by production of mutated cMyBP-C with reduced binding to actin
Godiksen MTN, et al.
Open Journal of Veterinary Medicine, 3(02), 95-95 (2013)
Synergistic effects of glucose and ultraviolet irradiation on the physical properties of collagen
Ohan MP, et al.
Journal of Biomedical Materials Research, 60(3), 384-391 (2002)
Protocol: Optimised methodology for isolation of nuclei from leaves of species in the Solanaceae and Rosaceae families
Sikorskaite S, et al.
Plant methods, 9(1), 31-31 (2013)
Extraction of Intracellular and Cell Wall Proteins from Leaves and Roots of Harsh Hakea
Shane MW and Plaxton WC
Journal of Experimental Botany (2014)
Mechanism of the reduction of methylene blue by thiourea in aqueous acidic medium
Osunlaja AA
International Journal of ChemTech Research, 4(2), 609-617 (2012)
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