All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C19H22FN3O3
CAS Number:
Molecular Weight:
359.39
Beilstein:
5307824
MDL number:
UNSPSC Code:
41116105
PubChem Substance ID:
NACRES:
NA.21
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Quality Level
Assay
≥99.0%
99.0-101.0% (dried substance)
form
powder or crystals
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
Mode of action
DNA synthesis | interferes
enzyme | inhibits
SMILES string
CCN1CCN(CC1)c2cc3N(C=C(C(O)=O)C(=O)c3cc2F)C4CC4
InChI
1S/C19H22FN3O3/c1-2-21-5-7-22(8-6-21)17-10-16-13(9-15(17)20)18(24)14(19(25)26)11-23(16)12-3-4-12/h9-12H,2-8H2,1H3,(H,25,26)
InChI key
SPFYMRJSYKOXGV-UHFFFAOYSA-N
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General description
Chemical structure: fluoroquinolone
Enrofloxacin is a veterinary fluoroquinolone (FQ) antibiotic with broad-spectrum antimicrobial activity. FQ drugs chelate to iron with high affinity. This chelation leads to inhibition of Fe(II)-dependent dioxygenases involved in the regulation of epigenetic control, collagen maturation, and HIF (hypoxia-inducible factor) degradation. The side effects associated with FQ drugs are renal toxicity and tendinopathy. Enrofloxacin is used in aquaculture and its use may cause an increase in the growth of antibiotic resistant microbes in an aquatic environment. The drug may have negative effects on public health and environment.
Application
Enrofloxacin has been used:
- to investigate the pathological mechanisms resulting from the toxicity of fluoroquinolones in mammalian cells
- to prepare a standard solution with 50% acetonitrile in a study to analyze illegal fish drugs used in aquaculture by employing surface-enhanced Raman spectroscopy (SERS)
- as an analyte in a chemiluminescence reagent system
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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