790451

TCO-amine HCl salt

• Synonym(s): trans-Cyclooctene-amine hydrochloride salt, TCO-NH2, HCl salt
• Empirical Formula (Hill Notation): C₁₂H₂₂N₂O₂ · HCl
• Molecular Weight: 262.78
• UNSPSC Code: 12352116
• PubChem Substance ID: 329768216
• NACRES: NA.22

Properties

• form: solid
• reaction suitability: reaction type: click chemistry; reagent type: linker
• functional group: amine
• storage temp.: −20°C
• SMILES string: O=C(NCCCN)OC1CCC/C=C/CC1.[H]Cl
• InChI: 1S/C12H22N2O2.ClH/c13-9-6-10-14-12(15)16-11-7-4-2-1-3-5-8-11;/h1-2,11H,3-10,13H2,(H,14,15);1H/b2-1+;
• InChI key: GIYQQURLGCGUKK-TYYBGVCCSA-N

Description

Application

Amine functionalized trans-cyclooctene derivative for incorporation of the cyclooctene moiety into carboxyl containing compounds or biomolecules via standard coupling techniques (DCC; EDC etc...). Trans-cyclooctenes are useful in strain-promoted copper-free click chemistry cycloaddition reactions with 1; 2; 4; 5-tetrazines. This cyclooctene will react with tetrazine functionalized compounds or biomolecules without the need for a catalyst to result in a stable covalent linkage. The 4+2 inverse electron demand Diels-Alder cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported and has had many applications in biological labeling and imaging.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable