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Merck

CTNNB1

catenin (cadherin-associated protein), beta 1, 88kDa

Synonyms:
CTNNB, MRD19, armadillo
Species:
UniProtKB ID:
Gene ID:
  • Human(1499) Summary: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009]
  • Mouse(12387) catenin (cadherin associated protein), beta 1
  • Rat(84353) catenin (cadherin associated protein), beta 1
  • naked mole-rat(101720578) catenin (cadherin-associated protein), beta 1, 88kDa
  • domestic guinea pig(100732604) catenin (cadherin-associated protein), beta 1, 88kDa
  • sheep(100294600) catenin (cadherin-associated protein), beta 1, 88kDa
  • Domestic Rabbit(100125985) catenin (cadherin-associated protein), beta 1, 88kDa
  • Zebrafish(30265) catenin (cadherin-associated protein), beta 1
  • chicken(395964) catenin (cadherin-associated protein), beta 1, 88kDa
  • cow(539003) catenin (cadherin-associated protein), beta 1, 88kDa
  • Horse(100055241) catenin (cadherin-associated protein), beta 1, 88kDa
  • domestic cat(101097342) catenin (cadherin-associated protein), beta 1, 88kDa
  • dog(477032) catenin (cadherin-associated protein), beta 1, 88kDa

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Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-CTNNB1 antibody produced in mouse, clone 1C9, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence

proximity ligation assay

western blot
Monoclonal Anti-phospho-β-Catenin (pSer33) antibody produced in mouse, clone BC-76, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
microarray
western blot
Anti-phospho-β-catenin (pTyr333) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-Phospho-CTNNB1-T41/S45 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-Phospho-beta Catenin-S675 antibody produced in rabbit, ,
Species Reactivity
human, rat
Application
western blot

Cell Lines

Product Number
Description
Species
A549 Cells GFP-CTNNB1 RFP-LMNB1, ,
Species
human

Proteins

Product Number
Description
Species
Catenin β, GST tagged human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human CTNNB1,
Species
human
MISSION® esiRNA, targeting mouse Ctnnb1,
Species
mouse