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  • Identifying key regulating miRNAs in hepatocellular carcinomas by an omics' method.

Identifying key regulating miRNAs in hepatocellular carcinomas by an omics' method.

Oncotarget (2017-12-22)
Bing He, Peng Lu, Lei Guan, Ting Li, Lei Zhang, Qing-Ge Zhu, Xiao-Xiao Ding, Shi-Ming Zhang, Xue-Mei Chen, Jing Zhao, Song Lin, Zhi-Zhen Liu, Fang-E Liu, Wang Ma, Hu-Qin Zhang
PMID29262610
ABSTRACT

The miRNAs play important regulating roles in the pathogenesis of hepatocellular carcinoma (HCC). To uncover key regulating miRNAs in HCC that were neglected by traditional analyzing methods of transcriptomics data, we proposed a novel molecular-network-based omics' (MNBO) method. With this method, we predicted HCC-regulating miRNAs, and confirmed the role of a novel miR-590-3P/