- SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage.
SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage.
American journal of physiology. Lung cellular and molecular physiology (2016-11-07)
Samik Bindu, Vinodkumar B Pillai, Abhinav Kanwal, Sadhana Samant, Gökhan M Mutlu, Eric Verdin, Nickolai Dulin, Mahesh P Gupta
PMID27815257
ABSTRACT
Myofibroblast differentiation is a key process in the pathogenesis of fibrotic diseases. Transforming growth factor-β