Skip to Content
Merck

Porous polysulfone coatings for enhanced drug delivery.

Biomedical microdevices (2012-03-07)
Kartik M Sivaraman, Christoph Kellenberger, Salvador Pané, Olgaç Ergeneman, Tessa Lühmann, Norman A Luechinger, Heike Hall, Wendelin J Stark, Bradley J Nelson
ABSTRACT

The synthesis of a porous polysulfone (PSU) coating for use in drug delivery applications is presented. PSU can serve as a functional surface coating for drug delivery vehicles, such as intraocular biomicrorobots. The coatings can be applied using spin coating or dip coating. The porosity is introduced by selectively dissolving calcium carbonate nanoparticles embedded in the bulk polymer. The network of pores thus formed increases by a factor of thirty the amount of Rhodamine B (model drug) that can be loaded and by a factor of fifteen the amount that can be released. The films do not affect cell viability and exhibit poor cell adhesion. The straightforward synthesis and predictability of porosity enables the tuning of the amount of drug that can be loaded.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Polysulfone, average Mw ~35,000 by LS, average Mn ~16,000 by MO, pellets (Transparent)
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Polysulfone, average Mn ~22,000 by MO, beads
SKU
Pack Size
Availability
Price
Quantity