One-pot, direct incorporation of [11C]CO2 into carbamates.

One-pot, direct incorporation of [11C]CO2 into carbamates.

Angewandte Chemie (International ed. in English) (2009-04-08)

Jacob M Hooker, Achim T Reibel, Sidney M Hill, Michael J Schueller, Joanna S Fowler

PMID19350593

ABSTRACT

Why beat about the bush? An operationally simple and mild reaction based on the direct fixation of (11)CO(2) with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) has been developed for the synthesis of (11)C-labeled carbamates at 75 degrees C within 10 minutes in radiochemical yields above 70% (see scheme). This strategy should be immediately useful for the construction of new radiotracers for positron emission tomography and other applications.

MATERIALS

Product Number

Brand

Product Description

714852

Sigma-Aldrich

1,8-Diazabicyclo[5.4.0]undec-7-ene solution, 1 M in THF

139009

Sigma-Aldrich

1,8-Diazabicyclo[5.4.0]undec-7-ene, 98%

33482

Sigma-Aldrich

1,8-Diazabicyclo[5.4.0]undec-7-ene, puriss., ≥99.0% (GC)