- Determination of benzodiazepines in blood and in dried blood spots collected from post-mortem samples and evaluation of the stability over a three-month period.
Determination of benzodiazepines in blood and in dried blood spots collected from post-mortem samples and evaluation of the stability over a three-month period.
Drug testing and analysis (2019-05-28)
Matteo Moretti, Francesca Freni, Ilaria Tomaciello, Claudia Vignali, Angelo Groppi, Silvia Damiana Visonà, Luca Tajana, Antonio Marco Maria Osculati, Luca Morini
PMID31125516
ABSTRACT
We successfully developed and validated an LC-MS/MS method for the identification of 27 and quantification of 9 benzodiazepines and metabolites in whole blood and DBSs. The results provided a good qualitative and quantitative correlation between DBSs stored at room temperature and whole blood stored at -20°C. A good stability for a three-month period was observed for most of the compounds detected in real post-mortem samples.
MATERIALS