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Merck

ZYX

zyxin

Synonyms:
ESP-2, HED-2
Species:
Human ZYX (7791), Mouse Zyx (22793), Rat Zyx (114636), fruit fly Zyx (317824), dog ZYX (482736), domestic cat ZYX (101099953), Zebrafish zyx (564246), chicken ZYX (418300), cow ZYX (768226), sheep ZYX (101123626) ...More
UniProtKB ID:
Q15942, A4D2G6, Q6I9S4
Gene ID:
  • Human(7791) Summary: Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]
  • Mouse(22793) zyxin
  • Rat(114636) zyxin
  • fruit fly(317824) Zyxin
  • dog(482736) zyxin
  • domestic cat(101099953) zyxin
  • Zebrafish(564246) zyxin
  • chicken(418300) zyxin
  • cow(768226) zyxin
  • sheep(101123626) zyxin
  • domestic guinea pig(100727523) zyxin
  • naked mole-rat(101710025) zyxin

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Antibodies

Product Number
Description
Species Reactivity
Application
Z4751
Anti-Zyxin antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
western blot
Z0377
Anti-Zyxin antibody, Mouse monoclonal, clone ZOL301, purified from hybridoma cell culture,
Species Reactivity
human, mouse, rat
Application
ELISA
immunocytochemistry
microarray
western blot