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Merck

WWOX

WW domain containing oxidoreductase

Synonyms:
D16S432E, FOR, FRA16D, HHCMA56, PRO0128, SDR41C1, WOX1
Species:
Human WWOX (51741), Mouse Wwox (80707), Rat Wwox (292041), fruit fly Wwox (34090), chicken WWOX (415801), Zebrafish wwox (393887), Horse WWOX (100055545), domestic cat WWOX (101093411), dog WWOX (610120), domestic guinea pig Wwox (100722863) ...More
UniProtKB ID:
Q9NZC7, A8K323, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4
Gene ID:
  • Human(51741) Summary: WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008]
  • Mouse(80707) WW domain-containing oxidoreductase
  • Rat(292041) WW domain-containing oxidoreductase
  • fruit fly(34090) WW domain containing oxidoreductase
  • chicken(415801) WW domain containing oxidoreductase
  • Zebrafish(393887) WW domain containing oxidoreductase
  • Horse(100055545) WW domain containing oxidoreductase
  • domestic cat(101093411) WW domain containing oxidoreductase
  • dog(610120) WW domain containing oxidoreductase
  • domestic guinea pig(100722863) WW domain containing oxidoreductase
  • naked mole-rat(101698327) WW domain containing oxidoreductase
  • Domestic Rabbit(100353596) WW domain containing oxidoreductase
  • cow(618792) WW domain containing oxidoreductase
  • sheep(101120431) WW domain containing oxidoreductase

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB4504681
Anti-phospho-WWOX (pTyr33) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
SAB1401709
Anti-WWOX antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot