WFDC1
WAP four-disulfide core domain 1
Synonyms:
PS20
Species:
Human WFDC1 (58189), Mouse Wfdc1 (67866), Rat Wfdc1 (171112), cow WFDC1 (505366), sheep WFDC1 (101102920), domestic guinea pig Wfdc1 (100727072), naked mole-rat Wfdc1 (101710653), Zebrafish wfdc1 (560860), domestic cat WFDC1 (101088637), dog WFDC1 (489682)
UniProtKB ID:
Gene ID:
- Human(58189) Summary: This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. The encoded protein shares 81% amino acid identity with the rat ps20 protein, which was originally identified as a secreted growth inhibitor. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. Owing to its location and a possible growth inhibitory property of its gene product, this gene is suggested to be a tumor suppressor gene. [provided by RefSeq, Jul 2008]
- Mouse(67866) WAP four-disulfide core domain 1
- Rat(171112) WAP four-disulfide core domain 1
- cow(505366) WAP four-disulfide core domain 1
- sheep(101102920) WAP four-disulfide core domain 1
- domestic guinea pig(100727072) WAP four-disulfide core domain 1
- naked mole-rat(101710653) WAP four-disulfide core domain 1
- Zebrafish(560860) WAP four-disulfide core domain 1
- domestic cat(101088637) WAP four-disulfide core domain 1
- dog(489682) WAP four-disulfide core domain 1
- chicken(395238) WAP four-disulfide core domain 1
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