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Merck

SETD2

SET domain containing 2

Synonyms:
HBP231, HIF-1, HIP-1, HYPB, KMT3A, SET2, p231HBP
Species:
UniProtKB ID:
Gene ID:
  • Human(29072) Summary: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]
  • Mouse(235626) SET domain containing 2
  • Rat(316013) SET domain containing 2
  • Zebrafish(794199) SET domain containing 2
  • Horse(100064888) SET domain containing 2
  • domestic cat(101085029) SET domain containing 2
  • dog(476643) SET domain containing 2
  • chicken(420404) SET domain containing 2
  • cow(539860) SET domain containing 2
  • naked mole-rat(101719404) SET domain containing 2
  • domestic guinea pig(100719166) SET domain containing 2

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Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-SETD2 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL9956, purified immunoglobulin, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-SETD2 antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-SETD2 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
canine, human, mouse, pig
Application
ELISA
western blot
Anti-SETD2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
Anti-SETD2 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
western blot

Proteins

Product Number
Description
Species
SETD2 active human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Setd2,
Species
mouse