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Merck

PRKCH

protein kinase C, eta

Synonyms:
PKC-L, PKCL, PRKCL, nPKC-eta
Species:
Human PRKCH (5583), Mouse Prkch (18755), Rat Prkch (81749), cow PRKCH (518542), sheep PRKCH (101105574), naked mole-rat Prkch (101716769), Domestic Rabbit PRKCH (100344184), domestic guinea pig Prkch (100736222), chicken PRKCH (423518), Horse PRKCH (100051560) ...More
UniProtKB ID:
P24723, Q16246, Q8NE03
Gene ID:
  • Human(5583) Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. [provided by RefSeq, Jul 2008]
  • Mouse(18755) protein kinase C, eta
  • Rat(81749) protein kinase C, eta
  • cow(518542) protein kinase C, eta
  • sheep(101105574) protein kinase C, eta
  • naked mole-rat(101716769) protein kinase C, eta
  • Domestic Rabbit(100344184) protein kinase C, eta
  • domestic guinea pig(100736222) protein kinase C, eta
  • chicken(423518) protein kinase C, eta
  • Horse(100051560) protein kinase C, eta
  • domestic cat(101082413) protein kinase C, eta
  • dog(490722) protein kinase C, eta

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Small Molecule - Agonist

Product Number
Description
Species
O1008
Oleic acid, ≥99% (GC),
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
SAB1401308
Anti-PRKCH antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
07-877
Anti-phospho-PKCη (Thr655) Antibody, Upstate®, from rabbit,
Species Reactivity
human
Application
western blot
SAB4504099
Anti-phospho-PKC-pan (pThr497) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
X600
Xanthone, 97%,
Species
mouse
I7016
H-7 dihydrochloride, ≥98% (HPLC),
Species
human
T9262
Tamoxifen citrate salt, ≥99%,
Species
human
O1008
Oleic acid, ≥99% (GC),
Species
human
U6508
UCN-01, ≥97% (HPLC), powder,
Species
human

Proteins

Product Number
Description
Species
K4143
PKCη, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human