PRKCA
protein kinase C, alpha
Synonyms:
AAG6, PKC-alpha, PKCA, PRKACA
Species:
Human PRKCA (5578), Mouse Prkca (18750), Rat Prkca (24680), cow PRKCA (282001), sheep PRKCA (101110074), naked mole-rat Prkca (101716044), Domestic Rabbit PRKCA (100037720), domestic guinea pig Prkca (100302324), domestic guinea pig Prkca (100713627), Zebrafish prkca (497384) ...More
UniProtKB ID:
Gene ID:
- Human(5578) Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]
- Mouse(18750) protein kinase C, alpha
- Rat(24680) protein kinase C, alpha
- cow(282001) protein kinase C, alpha
- sheep(101110074) protein kinase C, alpha
- naked mole-rat(101716044) protein kinase C, alpha
- Domestic Rabbit(100037720) protein kinase C, alpha
- domestic guinea pig(100302324) protein kinase C, alpha
- domestic guinea pig(100713627) protein kinase C, alpha
- Zebrafish(497384) protein kinase C, alpha
- domestic cat(101086433) protein kinase C, alpha
- Horse(100063318) protein kinase C, alpha
- dog(490904) protein kinase C, alpha
- chicken(417430) protein kinase C, alpha
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Small Molecule - Activator
Product Number
Description
Species
Small Molecule - Agonist
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-phospho-PKC α (pTyr658) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
western blot
Anti-PKC α antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PKC Antibody (α, β, γ), clone M110, clone M110, Upstate®, from mouse,
Species Reactivity
human, mouse, rat
Application
ELISA
immunocytochemistry
immunoprecipitation (IP)
western blot
immunocytochemistry
immunoprecipitation (IP)
western blot
Anti-Phospho-PKC alpha-S657/Y658 antibody produced in rabbit, ,
Species Reactivity
human, mouse
Application
western blot
Anti-Phospho-PKC alpha-T638 antibody produced in rabbit, ,
Species Reactivity
human
Application
western blot
Small Molecule - Inhibitor
Product Number
Description
Species
Proteins
Product Number
Description
Species
Protein kinase Cα isozyme human, ≥70% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution,
Species
human
PKC-α, active, GST tagged from Xanopus sp., PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
PKCα Protein, active, 10 µg, Active, recombinant, full-length human PKCα, containing N-terminal His6 tag. For use in Kinase Assays.,
Species
human
Small Molecule - Substrate
Product Number
Description
Species