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Merck

PARP1

poly (ADP-ribose) polymerase 1

Synonyms:
ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1
Species:
Human PARP1 (142), Mouse Parp1 (11545), Rat Parp1 (25591), Thale Cress PARP1 (817690), Zebrafish parp1 (560788), chicken PARP1 (396199), dog PARP1 (490385), domestic cat PARP1 (101081434), Horse PARP1 (100058523), cow PARP1 (286764) ...More
UniProtKB ID:
P09874, B1ANJ4, Q8IUZ9
Gene ID:
  • Human(142) Summary: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
  • Mouse(11545) poly (ADP-ribose) polymerase family, member 1
  • Rat(25591) poly (ADP-ribose) polymerase 1
  • Thale Cress(817690) poly [ADP-ribose] polymerase 2
  • Zebrafish(560788) poly (ADP-ribose) polymerase family, member 1
  • chicken(396199) poly (ADP-ribose) polymerase 1
  • dog(490385) poly (ADP-ribose) polymerase 1
  • domestic cat(101081434) poly (ADP-ribose) polymerase 1
  • Horse(100058523) poly (ADP-ribose) polymerase 1
  • cow(286764) poly (ADP-ribose) polymerase 1
  • domestic guinea pig(100733925) poly (ADP-ribose) polymerase 1
  • naked mole-rat(101703207) poly (ADP-ribose) polymerase 1
  • sheep(100135697) poly (ADP-ribose) polymerase 1

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Antibodies

Product Number
Description
Species Reactivity
Application
WH0000142M1
Monoclonal Anti-PARP1 antibody produced in mouse, clone 3G4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot
SAB4500488
Anti-PARP (Cleaved-Gly215) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
western blot
AV33754
Anti-PARP1 antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
SAB5700016
Anti-PARP1 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
ChIP
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
SAB5701295
Anti- Cleaved PARP1 p25 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
A0788
3-Aminobenzamide, ≥99% (TLC),
Species
mouse
299634
6-(5H)-Phenanthridinone, technical grade,
Species
human
135828
Benzamide, 99%,
Species
human
399337
Benzamide, purified by sublimation, ≥99.5%,
Species
human
47865-U
Nicotinamide (Niacinamide), analytical standard,
Species
human

Proteins

Product Number
Description
Species
SRP0192
PARP1 Active human, recombinant, expressed in baculovirus infected insect cells, ≥80% (SDS-PAGE),
Species
human
P0996
PARP-1 human, recombinant, expressed in E. coli,
Species
human

esiRNA

Product Number
Description
Species
EHU050101
MISSION® esiRNA, targeting human PARP1,
Species
human