NR1I2
nuclear receptor subfamily 1, group I, member 2
Synonyms:
BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR
Species:
Human NR1I2 (8856), Mouse Nr1i2 (18171), Rat Nr1i2 (84385), Zebrafish nr1i2 (565875), dog NR1I2 (403482), cow NR1I2 (493713), domestic cat NR1I2 (101088355), domestic guinea pig Nr1i2 (100719967), naked mole-rat Nr1i2 (101722589), sheep NR1I2 (101118075)
UniProtKB ID:
Gene ID:
- Human(8856) Summary: This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]
- Mouse(18171) nuclear receptor subfamily 1, group I, member 2
- Rat(84385) nuclear receptor subfamily 1, group I, member 2
- Zebrafish(565875) nuclear receptor subfamily 1, group I, member 2
- dog(403482) nuclear receptor subfamily 1, group I, member 2
- cow(493713) nuclear receptor subfamily 1, group I, member 2
- domestic cat(101088355) nuclear receptor subfamily 1, group I, member 2
- domestic guinea pig(100719967) nuclear receptor subfamily 1, group I, member 2
- naked mole-rat(101722589) nuclear receptor subfamily 1, group I, member 2
- sheep(101118075) nuclear receptor subfamily 1, group I, member 2
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-NR1I2 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, rat
Application
immunofluorescence
western blot
western blot
Proteins
Product Number
Description
Species
Pregnane X receptor (138-434), His tagged human, recombinant, expressed in E. coli, ≥85% (SDS-PAGE),
Species
human