LAMB2
laminin, beta 2 (laminin S)
Synonyms:
LAMS, NPHS5
Species:
Human LAMB2 (3913), Mouse Lamb2 (16779), Rat Lamb2 (25473), Zebrafish lamb2 (337767), chicken LAMB2 (373980), cow LAMB2 (520167), domestic cat LAMB2 (101082047), dog LAMB2 (476626), sheep LAMB2 (101106719), domestic guinea pig Lamb2 (100732418)
UniProtKB ID:
Gene ID:
- Human(3913) Summary: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 2. The beta 2 chain contains the 7 structural domains typical of beta chains of laminin, including the short alpha region. However, unlike beta 1 chain, beta 2 has a more restricted tissue distribution. It is enriched in the basement membrane of muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle. Transgenic mice in which the beta 2 chain gene was inactivated by homologous recombination, showed defects in the maturation of neuromuscular junctions and impairment of glomerular filtration. Alternative splicing involving a non consensus 5' splice site (gc) in the 5' UTR of this gene has been reported. It was suggested that inefficient splicing of this first intron, which does not change the protein sequence, results in a greater abundance of the unspliced form of the transcript than the spliced form. The full-length nature of the spliced transcript is not known. [provided by RefSeq, Aug 2011]
- Mouse(16779) laminin, beta 2
- Rat(25473) laminin, beta 2
- Zebrafish(337767) laminin, beta 2 (laminin S)
- chicken(373980) laminin, beta 2 (laminin S)
- cow(520167) laminin, beta 2 (laminin S)
- domestic cat(101082047) laminin, beta 2 (laminin S)
- dog(476626) laminin, beta 2 (laminin S)
- sheep(101106719) laminin, beta 2 (laminin S)
- domestic guinea pig(100732418) laminin, beta 2 (laminin S)
- naked mole-rat(101706277) laminin, beta 2 (laminin S)
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-LAMB2 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL2976, purified immunoglobulin, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Monoclonal Anti-LAMB2 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL2979, purified immunoglobulin, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-Laminin B2 Antibody, clone A5, clone A5, Upstate®, from rat,
Species Reactivity
human, mouse
Application
immunohistochemistry
immunoprecipitation (IP)
immunoprecipitation (IP)
Monoclonal Anti-Laminin antibody produced in mouse, clone LAM-89, ascites fluid,
Species Reactivity
feline, human, pig
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Proteins
Product Number
Description
Species