IMPA1
inositol(myo)-1(or 4)-monophosphatase 1
Synonyms:
IMP, IMPA
Species:
Human IMPA1 (3612), Mouse Impa1 (55980), Rat Impa1 (83523), Zebrafish impa1 (437018), chicken IMPA1 (420199), dog IMPA1 (477925), domestic cat IMPA1 (101088214), cow IMPA1 (281865), sheep IMPA1 (101119912), domestic guinea pig Impa1 (100723610)
UniProtKB ID:
Gene ID:
- Human(3612) Summary: This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Nov 2009]
- Mouse(55980) inositol (myo)-1(or 4)-monophosphatase 1
- Rat(83523) Inositol (myo)-1(or 4)-monophosphatase 1
- Zebrafish(437018) inositol(myo)-1(or 4)-monophosphatase 1
- chicken(420199) inositol(myo)-1(or 4)-monophosphatase 1
- dog(477925) inositol(myo)-1(or 4)-monophosphatase 1
- domestic cat(101088214) inositol(myo)-1(or 4)-monophosphatase 1
- cow(281865) inositol(myo)-1(or 4)-monophosphatase 1
- sheep(101119912) inositol(myo)-1(or 4)-monophosphatase 1
- domestic guinea pig(100723610) inositol(myo)-1(or 4)-monophosphatase 1
- naked mole-rat(101704416) inositol(myo)-1(or 4)-monophosphatase 1
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Small Molecule - Inhibitor
Product Number
Description
Species
Lithium carbonate, puriss. p.a., ACS reagent, reagent (for microscopy), ≥99.0% (T),
Species
human