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Merck

HERC4

HECT and RLD domain containing E3 ubiquitin protein ligase 4

Synonyms:
Species:
Human HERC4 (26091), Mouse Herc4 (67345), Rat Herc4 (309758), sheep HERC4 (101103532), Domestic Rabbit HERC4 (100348847), domestic guinea pig Herc4 (100717289), naked mole-rat Herc4 (101725893), Zebrafish herc4 (557513), dog HERC4 (479225), chicken HERC4 (423683)
UniProtKB ID:
Q5GLZ8, Q5GC98, Q5GC99, Q5GCA0, Q8IXP9, Q9HCH9
Gene ID:
  • Human(26091) Summary: HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]
  • Mouse(67345) hect domain and RLD 4
  • Rat(309758) HECT and RLD domain containing E3 ubiquitin protein ligase 4
  • sheep(101103532) HECT and RLD domain containing E3 ubiquitin protein ligase 4
  • Domestic Rabbit(100348847) HECT and RLD domain containing E3 ubiquitin protein ligase 4
  • domestic guinea pig(100717289) HECT and RLD domain containing E3 ubiquitin protein ligase 4
  • naked mole-rat(101725893) HECT and RLD domain containing E3 ubiquitin protein ligase 4
  • Zebrafish(557513) hect domain and RLD 4
  • dog(479225) HECT and RLD domain containing E3 ubiquitin protein ligase 4
  • chicken(423683) HECT and RLD domain containing E3 ubiquitin protein ligase 4
  • cow(533336) HECT and RLD domain containing E3 ubiquitin protein ligase 4

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