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Merck

CYP11B1

cytochrome P450, family 11, subfamily B, polypeptide 1

Synonyms:
CPN1, CYP11B, FHI, P450C11
Species:
Human CYP11B1 (1584), Mouse Cyp11b1 (110115), Rat Cyp11b1 (500892), domestic guinea pig Cyp11b1 (100135511), sheep CYP11B1 (767576), cow CYP11B1 (282422)
UniProtKB ID:
P15538, Q14095, Q4VAQ8, Q4VAQ9, Q9UML2
Gene ID:
  • Human(1584) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(110115) cytochrome P450, family 11, subfamily b, polypeptide 1
  • Rat(500892) cytochrome P450, family 11, subfamily b, polypeptide 1
  • domestic guinea pig(100135511) cytochrome P450, family 11, subfamily b, polypeptide 1
  • sheep(767576) cytochrome P450, family 11, subfamily B, polypeptide 1
  • cow(282422) cytochrome P450, subfamily XI B, polypeptide 1

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Antibodies

Product Number
Description
Species Reactivity
Application
MAB6020
Anti-Cytochrome P450 11β-Hydroxylase Antibody, clone 11B2-1A4, culture supernatant, clone 11B2-1A4, Chemicon®,
Species Reactivity
rat
Application
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
35485
2,4′-DDD, PESTANAL®, analytical standard,
Species
human
1445007
Mitotane, United States Pharmacopeia (USP) Reference Standard,
Species
human
44012
1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland,
Species
human
K1003
Ketoconazole, 99.0-101.0% (EP, titration),
Species
mouse, human, rat