CHEK1
checkpoint kinase 1
Synonyms:
CHK1
Species:
Human CHEK1 (1111), Mouse Chek1 (12649), Rat Chek1 (140583), Zebrafish chek1 (393162), domestic cat CHEK1 (101083365), Horse CHEK1 (100064353), cow CHEK1 (513678), dog CHEK1 (609767), sheep CHEK1 (101111403), naked mole-rat Chek1 (101701035)
UniProtKB ID:
Gene ID:
- Human(1111) Summary: The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
- Mouse(12649) checkpoint kinase 1
- Rat(140583) checkpoint kinase 1
- Zebrafish(393162) CHK1 checkpoint homolog (S. pombe)
- domestic cat(101083365) checkpoint kinase 1
- Horse(100064353) checkpoint kinase 1
- cow(513678) CHK1 checkpoint homolog (S. pombe)
- dog(609767) checkpoint kinase 1
- sheep(101111403) checkpoint kinase 1
- naked mole-rat(101701035) checkpoint kinase 1
- domestic guinea pig(100719613) checkpoint kinase 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Chk1 antibody, Mouse monoclonal, ~2 mg/mL, clone DCS-310, purified from hybridoma cell culture,
Species Reactivity
human
Application
immunohistochemistry
immunoprecipitation (IP)
microarray
western blot
immunoprecipitation (IP)
microarray
western blot
Anti-phospho-Chk1 (pSer345) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
immunohistochemistry
Anti-phospho-Chk1 (pSer296) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-Phospho-CHEK1-S280 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Phospho-CHEK1-S296 antibody produced in rabbit, ,
Species Reactivity
human, mouse
Application
immunofluorescence
western blot
western blot
Small Molecule - Inhibitor
Product Number
Description
Species
Proteins
Product Number
Description
Species
CHK1, active, His tagged human, PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
CHK1, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
CHK1 Protein, active, 10 µg, Active, N-terminal GST tagged, human full length CHK1, for use in Kinase Assays.,
Species
human
Small Molecule - Substrate
Product Number
Description
Species
CHKtide (CHK1/CHK2 substrate peptide), CHKtide (CHK1/CHK2 substrate peptide) primarily used in Kinase Assays.,
Species
human