CBFA2T2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
Synonyms:
EHT, MTGR1, ZMYND3, p85
Species:
Human CBFA2T2 (9139), Mouse Cbfa2t2 (12396), Rat Cbfa2t2 (296293), Zebrafish cbfa2t2 (100151413), chicken CBFA2T2 (419155), dog CBFA2T2 (477196), cow CBFA2T2 (527740), Horse CBFA2T2 (100069109), domestic cat CBFA2T2 (101090759), sheep CBFA2T2 (101110436) ...More
UniProtKB ID:
Gene ID:
- Human(9139) Summary: In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]
- Mouse(12396) core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human)
- Rat(296293) core-binding factor, runt domain, alpha subunit 2; translocated to, 2
- Zebrafish(100151413) core-binding factor, runt domain, alpha subunit 2; translocated to, 2
- chicken(419155) core-binding factor, runt domain, alpha subunit 2; translocated to, 2
- dog(477196) core-binding factor, runt domain, alpha subunit 2; translocated to, 2
- cow(527740) core-binding factor, runt domain, alpha subunit 2; translocated to, 2
- Horse(100069109) core-binding factor, runt domain, alpha subunit 2; translocated to, 2
- domestic cat(101090759) core-binding factor, runt domain, alpha subunit 2; translocated to, 2
- sheep(101110436) core-binding factor, runt domain, alpha subunit 2; translocated to, 2
- Domestic Rabbit(100357211) core-binding factor, runt domain, alpha subunit 2; translocated to, 2
- domestic guinea pig(100729254) core-binding factor, runt domain, alpha subunit 2; translocated to, 2
- naked mole-rat(101719942) core-binding factor, runt domain, alpha subunit 2; translocated to, 2
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