ADORA2A
adenosine A2a receptor
Synonyms:
A2aR, ADORA2, RDC8
Species:
Human ADORA2A (135), Mouse Adora2a (11540), Rat Adora2a (25369), sheep ADORA2A (101112926), naked mole-rat Adora2a (101718082), domestic guinea pig Adora2a (100135473), chicken ADORA2A (427705), dog ADORA2A (403960), cow ADORA2A (617828), Horse ADORA2A (100034039)
UniProtKB ID:
Gene ID:
- Human(135) Summary: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]
- Mouse(11540) adenosine A2a receptor
- Rat(25369) adenosine A2a receptor
- sheep(101112926) adenosine A2a receptor
- naked mole-rat(101718082) adenosine A2a receptor
- domestic guinea pig(100135473) adenosine A2a receptor
- chicken(427705) adenosine A2a receptor
- dog(403960) adenosine A2a receptor
- cow(617828) adenosine A2a receptor
- Horse(100034039) adenosine A2a receptor
- domestic cat(101080742) adenosine A2a receptor
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Small Molecule - Agonist
Product Number
Description
Species
Small Molecule - Antagonist
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-A2A Adenosine Receptor antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
canine, human
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-ADORA2A (C-terminal) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, canine, guinea pig, horse, human, mouse, rabbit, rat
Application
immunohistochemistry
western blot
western blot
Anti-ADORA2A antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunohistochemistry
immunofluorescence
immunohistochemistry
Anti-ADORA2A antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
flow cytometry
western blot
western blot
Anti-ADORA2A antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse
Application
western blot
Small Molecule - Inhibitor
Product Number
Description
Species
Small Molecule - Ligand
Product Number
Description
Species
Small Molecule - Mixed Agonist/Antagonist
Product Number
Description
Species
2-Fluoroadenine-9-β-D-arabinofuranoside, DNA synthesis and methylation inhibitor,
Species
rat, human