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Poloxamer 188 in Protein Formulation

WEBINAR

Poloxamer 188 finds wide application in the development and manufacturing process of pharmaceutical drug products. In liquid protein formulations, Poloxamer 188 (PLX188) is added to stabilize proteins against mechanical stress, ensuring the desired therapeutic activity and safety of biologics. In cell culture media, PLX188 is added as shear stress protector to prevent cell damage during the cultivation in bioreactor and guarantee optimal cell growth.

We will show how the performance of PLX188 in these applications can be affected by variations in molecular weight or hydrophobicity, observed among different batches or products.

In this webinar, you will learn:

the function of Poloxamer 188 as stabilizer in biopharmaceutical products
the function of Poloxamer 188 as shear stress protector in cell culture
the impact of material attributes on the different applications of Poloxamer 188 in liquid protein formulation and in cell culture media

Speakers

Nelli Erwin, Ph.D.

Merck

Senior Manager, Head of Protein Stability

Nelli heads the protein stability laboratory in process and formulation materials - technology and innovation (T&I) at Merck. In this role, she is mainly responsible for the development of new technologies to improve the stability of biomolecule formulations. Her previous work experience includes a postdoc position in Analytical R&D at AbbVie. She holds a Ph.D. from the Technical University of Dortmund in Chemical Biology, investigating the structure and dynamics of biomolecules.

Alice Antonello, Ph.D.

Merck

Senior Scientist - Bioprocess Chemistry

Alice Antonello is senior scientist in the bioprocess chemistry team in process and formulation materials - technology and innovation at Merck. She is mainly focused on the development and application of surfactants for bioprocessing, from cell cultivation to harvest and first treatments of the product. She holds a Ph.D. in Chemistry from Max Planck Institute for Polymer Research in Mainz.