RNAi Bibliographies

Looking for current application references in the field of RNAi?
Look no further.

Listed below are many of the top research articles relevant to RNAi and Functional Genomics research. Articles include shRNA, lentiviral-based systems, delivery to various cell lines and transgenic animals, as well as reviews on siRNA. All references are linked to PubMed, where you can find complete abstract information and relevant journal information.

If you would like a particular reference added to the current bibliography, please email us. If we are able, we will add it to the list.

Basic Mechanism
High-Throughput Screening
IPTG Inducible shRNA
In vivo Applications
In vivo Disease Treatment
Broad Publications
MISSION^® shRNA
MISSION^® siRNA Publications
Specific Applications
Assay Design

Reviews
High Titer
Screening
General RNAi
RNAi in Neurons
RNAi in Yeast and Overview of RNAi Machinery
In Vivo siRNA
shRNA Transduction of Human Primary T Cells
Pooled shRNA Screening and Deconvolution

Basic Mechanism

Title	Author / Journal	Abstract
Short hairpin RNA (shRNA): design, delivery, and assessment of gene knockdown.	Moore C.B., et al. Methods. Mol. Biol. 2010;629:141-58.	abstract
The RNA silencing technology applied by lentiviral vectors in oncology.	Sumimoto H., et al. Methods Mol. Biol. 2010;614:187-99.	abstract
Gene silencing by small regulatory RNAs in mammalian cells.	Scherr M., et al. Cell Cycle. 2007 Feb 15;6(4):444-9. Epub 2007 Feb 5. Review.	abstract
The silent treatment: RNAi as a defense against virus infection in mammals.	van Rij RP, Andino R. Trends Biotechnol. 2006. Apr;24(4):186-93. Epub 2006. Feb 28.	abstract
A Facile Lentiviral Vector System for Expression of Doxycycline-Inducible shRNAs: Knockdown of the Pre-miRNA Processing Enzyme Drosha.	Aagaard L, et al. Mol Ther. 2007. Feb 20.	abstract
RNA interference has a role in regulating Drosophila telomeres.	Casacuberta E, Pardue ML. Perrimon. Genome Biol. 2006. 7(5):220. Epub 2006 May 31. Review.	abstract
Is RNA interference involved in intrinsic antiviral immunity in mammals?	Cullen BR. Nat. Immunol. 2006. June; 7(6):563-7. Review.	abstract
Gene silencing of virus replication by RNA interference.	Miyano-Kurosaki N, Takaku H. Handb Exp Pharmacol. 2006;(173):151-71.	abstract
Exploring the functions of RNA interference pathway proteins: some functions are more RISCy than others?	Jaronczyk K, Carmichael JB, Hobman TC. Biochem. J.. 2005 May 1;387(Pt 3):561-71.	abstract
Viral delivery of recombinant short hairpin RNAs.	Davidson BL, Harper SQ. Methods Enzymol. 2005;392:145-73	abstract
Paradigms for conditional expression of RNA interference molecules for use against viral targets.	Strayer DS, Feitelson M., Sun B., Matskevich AA. Methods Enzymol. 2005;392:227-41	abstract
Small RNA asymmetry in RNAi: function in RISC assembly and gene regulation.	Hutvagner G. FEBS Lett. 2005 Oct 31;579(26):5850-7	abstract
Uncovering RNAi mechanisms in plants: biochemistry enters the foray.	Qi Y, Hannon GJ. FEBS Lett. 2005 Oct 31;579(26):5899-903	abstract
Plant pathology and RNAi: a brief history.	Lindbo JA, Dougherty WG. Annu Rev Phytopathol. 2005;43:191-204	abstract
RNAi: the nuts and bolts of the RISC machine.	Filipowicz W. Cell. 2005 Jul 15;122(1):17-20	abstract
Molecular mechanisms of RNAi: implications for development and disease.	Rao M, Sockanathan S. Birth Defects Res C Embryo Today. 2005 Mar;75(1):28-42	abstract
RNAi-mediated pathways in the nucleus.	Matzke MA, Birchler JA. Nat Rev Genet. 2005 Jan;6(1):24-35	abstract
Dicing and slicing: the core machinery of the RNA interference pathway.	Hammond SM. FEBS Lett. 2005 Oct 31;579(26):5822-9	abstract
RNA interference, transposon silencing, and cosuppression in the Caenorhabditis elegans germ line: similarities and differences.	Robert VJ, Vastenhouw NL, Plasterk RH. Cold Spring Harb Symp Quant Biol. 2004;69:397-402	abstract

High-Throughput Screening

Title	Author / Journal	Abstract
A comparison of multiple shRNA expression methods for combinatorial RNAi.	McIntyre G.J., et al. Genet Vaccines Ther. 2011 Apr 17;9(1):9. [Epub ahead of print]	abstract
A genome-wide RNAi screen identifies novel targets of neratinib sensitivity leading to neratinib and paclitaxel combination drug treatments.	Seyhan A.A., et al. Mol. Biosyst. 2011 Apr 12. [Epub ahead of print]	abstract
An RNAi screen identifies USP2 as a factor required for TNF-a induced NF-?B signaling.	Metzig M., et al. Int. J. Cancer. 2011 Apr 7. doi: 10.1002/ijc.26124. [Epub ahead of print]	abstract
Second-Generation Sequencing Supply an Effective Way to Screen RNAi Targets in Large Scale for Potential Application in Pest Insect Control.	Wang Y., et al. PLoS One. 2011 Apr 11;6(4):e18644.	abstract
RNAi-Based Screening Identifies Kinases Interfering with Dioxin-Mediated Up-Regulation of CYP1A1 Activity.	Gilot D., et al. PLoS One. 011 Mar 29;6(3):e18261.	abstract
Large scale RNAi screen reveals that the Inhibitor of DNA binding 2 (ID2) protein is repressed by p53 family member p63 and functions in human keratinocyte differentiation.	Wu N., et al. J. Biol. Chem.. 2011 Apr 10. [Epub ahead of print]	abstract
A genome-wide shRNA screen for new OxPhos related genes.	Bayona-Bafaluy M.P., et al. Mitochondrion. 2011 May;11(3):467-75. Epub 2011 Feb 1.	abstract
Random small interfering RNA library screen identifies siRNAs that induce human erythroleukemia cell differentiation.	Fan C., et al. Leuk. Lymphoma. Mar;52(3):502-14. Epub 2011 Feb 1.	abstract
RNAi-based functional pharmacogenomics.	Tuzmen S., et al. Methods Mol. Biol. 2011;700:271-90.	abstract
Vigilance and validation: Keys to success in RNAi screening.	Sigoillot F.D., et al. ACS Chem. Biol. 2011 Jan 21;6(1):47-60. Epub 2010 Dec 28. Review.	abstract
Validation of efficient high-throughput plasmid and siRNA transfection of human monocyte-derived dendritic cells without cell maturation.	Bowles R., et al. J. Immunol. Methods. 2010 Dec 15;363(1):21-8. Epub 2010 Sep 24.	abstract
An effective method for controlling false discovery and false nondiscovery rates in genome-scale RNAi screens. J Biomol Screen.	Zhang X.D. Pub. 2010 Oct;15(9):1116-22. Epub 2010 Sep 20.	abstract
High-throughput RNAi screening for N-glycosylation dependent loci in Caenorhabditis elegans.	Struwe W.B., et al. Methods Enzymol. 2010;480:477-93. Review.	abstract
RNAi screening of the kinome identifies modulators of cisplatin response in ovarian cancer cells.	Arora S., et al. Gynecol. Oncol. 2010 Sep;118(3):220-7.	abstract
RNAi phenotype profiling of kinases identifies potential therapeutic targets in Ewing's sarcoma.	Arora S., et al. Mol. Cancer. 2010 Aug 18;9:218.	abstract
Discovery of novel cell proliferation-enhancing gene by random siRNA library based combinatorial screening.	Xiong X., et al. Comb. Chem. High Throughput Screen. 2010 Nov 1;13(9):798-806.	abstract
Lentiviral shRNA screen of human kinases identifies PLK1 as a potential therapeutic target for osteosarcoma.	Duan Z., et al. Cancer Lett. 2010 Jul 28;293(2):220-9. Epub 2010 Feb 9.	abstract
Identification of inhibitors of HSF1 functional activity by high-content target-based screening.	Au Q., et al. J. Biomol. Screen. 2009 Dec;14(10):1165-75.	abstract
Illuminating the host - how RNAi screens shed light on host-pathogen interactions.	Prudêncio M., et al. Biotechnol J. 2009 Jun;4(6):826-37. Review.	abstract
Integrative analysis of genome-wide RNA interference screens.	Berndt J.D., et al. Sci. Signal. 2009 May 12;2(70):pt4.	abstract
Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells.	Ganesan A.K., et al. PLoS Genet. 2008 Dec;4(12):e1000298. Epub 2008 Dec 5.	abstract
Systems analysis of quantitative shRNA-library screens identifies regulators of cell adhesion.	Huang X., et al. BMC Syst Biol. 2008 Jun 13;2:49.	abstract
From sequence to function: using RNAi to elucidate mechanisms of human disease.	Author, et al. Cell Death Differ. 2008 May;15(5):809-19. Epub 2008 Jan 18.	abstract
An efficient and fully automated high-throughput transfection method for genome-scale siRNA screens.	Chung N., et al. J. Biomol. Screen. 2008 Feb;13(2):142-8. Epub 2008 Jan 23.	abstract
Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screens.	Perrimon N, Friedman A, Mathey-Prevot B, Eggert US. Drug Discov Today. 2007 Jan;12(1-2):28-33. Epub 2006 Oct 30	abstract
MDR1/P-glycoprotein (ABCB1) as target for RNA interference-mediated reversal of multidrug resistance.	Lage H. Curr Drug Targets. 2006. Jul; 7(7):813-21. Review.	abstract
High-throughput RNAi Screening in Cultured Cells: A User's Guide.	Echeverri, C. and N. Perrimon. Nature Reviews Genetics. 2006. 7, 373-384.	abstract
From genome to phenome--RNAi library screening and hit characterization using signaling pathway analysis.	Chatterjee-Kishore M. Curr Opin Drug Discov Devel. 2006 Mar;9(2):231-9.	abstract
High-throughput RNA interference in functional genomics	Janitz M, Vanhecke D, Lehrach H. Handb Exp Pharmacol. 2006;(173):97-104.	abstract
Exploring the sounds of silence: RNAi-mediated gene silencing for target identification and validation.	Chatterjee-Kishore M, Miller CP. Drug Discov Today. 2005 Nov 15;10(22):1559-65	abstract
Genome-wide application of RNAi to the discovery of potential drug targets.	Ito M, Kawano K, Miyagishi M, Taira K. FEBS Lett. 2005 Oct 31;579(26):5988-95	abstract
Genome-wide screening for gene function using RNAi in mammalian cells.	Cullen LM, Arndt GM. Immunol Cell Biol. 2005 Jun;83(3):217-23	abstract
RNAi and HTS: exploring cancer by systematic loss-of-function.	Willingham AT, Deveraux QL, Hampton GM, Aza-Blanc P. Oncogene. 2004 Nov 1;23(51):8392-400	abstract
Oncology studies using siRNA libraries: the dawn of RNAi-based genomics.	Sachse C, Echeverri CJ. Oncogene. 2004 Nov 1;23(51):8384-91	abstract

IPTG Inducible shRNA

Title	Author / Journal	Abstract
FOXO3a Is A Major Target Of Inactivation By PI3K/AKT Signaling In Aggressive Neuroblastoma	Santo, E.E., et al. Cancer Res. 2013 Feb 1. [Epub ahead of print]	abstract
Shifting the Paradigm: The Putative Mitochondrial Protein ABCB6 Resides in the Lysosomes of Cells and in the Plasma Membrane of Erythrocytes	Kiss, K., et al. PLoS One. 2012; 7(5)	abstract

In Vivo Applications

Title	Author / Journal	Abstract
Knock-down of gene expression in hematopoietic cells.	Scherr M., et al. Methods Mol Biol. 2009;506:207-19.	abstract
Reversible suppression of an essential gene in adult mice using transgenic RNA interference.	McJunkin K., et al. Proc. Natl. Acad. Sci. USA. 2011 Apr 11. [Epub ahead of print]	abstract
Asymmetric cell divisions promote Notch-dependent epidermal differentiation.	Williams, S.E., et al. Nature. 2011 Feb 17; 470 (7334): 353-358.	abstract
Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos.	Beronja, S., et al. Nat Med. 2010 Jul; 16(7):821-827.	abstract video
Critical role of prostate apoptosis response-4 in determining the sensitivity of pancreatic cancer cells to small-molecule inhibitor-induced apoptosis.	Azmi, A.S., et al. Mol Cancer Ther. 2008 Sep;7(9):2884-93.	abstract
Impact of tumor-specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA-containing nanoparticles.	Bartlett, D.W., et al. Biotechnol Bioeng. 2008 Mar 1;99(4):975-85.	abstract
A Transient Breach in the Epithelial Barrier Leads to Regulatory T-Cell Generation and Resistance to Experimental Colitis.	Boirivant, M., et al. Gastroenterology. 2008 Aug 5. [Epub ahead of print]	abstract
Glucose-regulated protein 78 regulates multiple malignant phenotypes in head and neck cancer and may serve as a molecular target of therapeutic intervention.	Chiu, C.C., et al. Mol Cancer Ther. 2008 Sep;7(9):2788-97.	abstract
Tumor necrosis factor alpha small interfering RNA decreases herpes simplex virus-induced inflammation in a mouse model.	Choi, B., et al. J Dermatol Sci. 2008 Nov;52(2):87-97. Epub 2008 Jun 27.	abstract
Delivery vehicles for small interfering RNA in vivo.	de Fougerolles, A.R. Hum Gene Ther. 2008 Feb;19(2):125-32.	abstract
Expression of CYP4A1 in U251 Human Glioma Cell Induces Hyperproliferative Phenotype in vitro and Rapidly Growing Tumors in vivo.	Guo, A.M., et al. J Pharmacol Exp Ther. 2008 Jun 30. [Epub ahead of print]	abstract
Single-nucleotide-specific siRNA targeting in a dominant-negative skin model.	Hickerson, R.P., et al. J Invest Dermatol. 2008 Mar;128(3):594-605. Epub 2007 Oct 11.	abstract
A small interfering RNA targeting proteinase-activated receptor-2 is effective in suppression of tumor growth in a Panc1 xenograft model.	Iwanki, K., et al. Int J Cancer. 2008 Feb 1;122(3):658-63.	abstract
Inhibition of retinal neovascularization by gene transfer of small interfering RNA targeting HIF-1alpha and VEGF.	Jiang, J., et al. J Cell Physiol. 2008 Sep 2. [Epub ahead of print]	abstract
Administration of PLK-1 small interfering RNA with atelocollagen prevents the growth of liver metastases of lung cancer.	Kawata, E., et al. Mol Cancer Ther. 2008 Sep;7(9):2904-12.	abstract
Silencing HIV-1 in vivo.	Kirchhoff, F. Cell. 2008 Aug 22;134(4):566-8.	abstract
Sequence- and target-independent angiogenesis suppression by siRNA via TLR3.	Kleinman, M.E., et al. Nature. 452, 591-7 (2008).	abstract
Oral cancer overexpressed 1 (ORAOV1): a regulator for the cell growth and tumor angiogenesis in oral squamous cell carcinoma.	Jiang, L., et al. Int J Cancer. Oct 2008; 123(8): 1779-86.	abstract
Inhibition of connective tissue growth factor by small interfering RNA prevents renal fibrosis in rats undergoing chronic allograft nephropathy.	Luo, G.H., et al. Transplant Proc. 2008 Sep;40(7):2365-9.	abstract
Misinterpreting the therapeutic effects of siRNA caused by immune stimulation.	Robbins, M., et al. Hum Gene Ther. Aug 19. [Epub ahead of print] (2008).	abstract
A dominant role of GTRAP3-18 in neuronal glutathione synthesis.	Watabe, M., et al. J Neurosci. 2008 Sep 17;28(38):9404-13.	abstract
Toll-like Receptor 3 and Geographic Atrophy in Age-Related Macular Degeneration.	Yang, Z., et al. N Engl J Med. Aug 27. [Epub ahead of print] (2008).	abstract
Down-regulation of beta1-adrenoceptors gene expression by short interfering RNA impairs the memory retrieval in the basolateral amygdala of rats.	Fu, A.L., et al. Neurosci Lett. 2007 Nov 27;428(2-3):77-81. Epub 2007 Sep 26.	abstract
In vivo gene silencing in solid tumors by targeted electrically mediated siRNA delivery.	Golzio, M., et al. Gene Ther. 2007 May;14(9):752-9. Epub 2007 Mar 8.	abstract
Modulation of scratching behavior by silencing an endogenous cyclooxygenase-1 gene in the skin through the administration of siRNA.	Inoue, T., et al. J Gene Med. 2007 Nov;9(11):994-1001.	abstract
Systemic and specific delivery of small interfering RNAs to the liver mediated by apolipoprotein A-I.	Kim, S.I., et al. Mol Ther. 2007 Jun;15(6):1145-52. Epub 2007 Apr 17.	abstract
Downregulation of mu opioid receptor by RNA interference in the ventral tegmental area reduces ethanol consumption in mice.	Lasek, A.W., et al. Genes Brain Behav. 2007. Mar 26.	abstract
Therapeutic RNA interference of malignant melanoma by electrotransfer of small interfering RNA targeting Mitf.	Nakai, N., et al. Gene Ther. 2007 Feb;14(4):357-65. Epub 2006 Oct 5.	abstract
Materializing the potential of small interfering RNA via a tumor-targeting nanodelivery system.	Pirollo, K.F., et al. Cancer Res. 2007 Apr 1;67(7):2938-43.	abstract
Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes.	Rozema, D.B., et al. Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):12982-7. Epub 2007 Jul 24.	abstract
A high throughput in vivo model for testing delivery and antiviral effects of siRNAs in vertebrates.	Schyth, B.D., et al. Mol Ther. 2007 Jul;15(7):1366-72. Epub 2007 May 1.	abstract
RNA interference targeting hypoxia inducible factor 1alpha reduces post-operative adhesions in rats.	Segura, T., et al. J Surg Res. 2007 Aug;141(2):162-70. Epub 2007 Jun 11.	abstract
Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis.	Shaw, A.T., et al. Genes Dev. 2007. Mar 15;21(6):694-707.	abstract
Liver target delivery of small interfering RNA to the HCV gene by lactosylated cationic liposome.	Watanabe, T., et al. J Hepatol. 2007 Dec;47(6):744-50. Epub 2007 Jul 26.	abstract
Efficient regulation of viral replication by siRNA in a non-human primate surrogate model for hepatitis C.	Yogota, T., et al. Biochem Biophys Res Commun. 2007 Sep 21;361(2):294-300. Epub 2007 Jul 16.	abstract
Gene silencing through RNA interference (RNAi) in vivo: strategies based on the direct application of siRNAs.	Aigner, A. J Biotechnology. 2006. Jun 25; 124(1): 12-25.	abstract
Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging.	Bartlett, D.W., et al. Nucleic Acids Res. 2006 Jan 12;34(1):322-33. Print 2006.	abstract
A single administration of lentiviral vectors expressing either full-length human immunodeficiency virus 1 (HIV-1)(HXB2) Rev/Env or codon-optimized HIV-1(JR-FL) gp120 generates durable immune responses in mice.	Buffa. V., et al. J Gen Virol. 2006 Jun;87(Pt 6):1625-34.	abstract
In vivo transduction by intravenous injection of a lentiviral vector expressing human ADA into neonatal ADA gene knockout mice: a novel form of enzyme replacement therapy for ADA deficiency.	Carbonaro, D.A., et al. Mol Ther. 2006 Apr 29; [Epub ahead of print]	abstract
RNA interference in cancer.	Gartel, A.L., et al. Biomol Eng. 2006 Mar;23(1):17-34. Epub 2006 Feb 8.	abstract
RNA interference: a potential therapeutic tool for silencing splice isoforms linked to human diseases.	Gaur, R.K. Biotechniques. 2006 Apr;Suppl:15-22. Review.	abstract
Supraspinal brain-derived neurotrophic factor signaling: a novel mechanism for descending pain facilitation.	Guo, W., et al. J Neurosci. 2006 Jan 4;26(1):126-37.	abstract
RNA interference: its use as antiviral therapy.	Haasnoot, J., et al. Handb Exp Pharmacol. 2006;(173):117-50.	abstract
RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system.	Howard, K.A., et al. Mol Ther. 2006 Oct;14(4):476-84. Epub 2006 Jul 10.	abstract
Suppression of complement regulatory proteins (CRPs) exacerbates experimental autoimmune anterior uveitis (EAAU).	Jha, P., et al. J Immunol. 2006 Jun 15;176(12):7221-31.	abstract
A single siRNA suppresses fatal encephalitis induced by two different flaviviruses.	Kumar, P., et al. PLoS Med. 2006 Apr;3(4):e96. Epub 2006 Feb 14.	abstract
Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras.	McNamara, J.O., 2nd, et al. Nat Biotechnol. 2006 Aug;24(8):1005-15. Epub 2006 Jun 25.	abstract
RNA silencing in vivo reveals role of p22phox in rat angiotensin slow pressor response.	Modlinger, P., et al. Hypertension. 2006 Feb;47(2):238-44. Epub 2006 Jan 3.	abstract
Antiviral applications of RNAi.	Morris K.V., and Rossi J.J. Curr Opin Mol Ther. 2006 Apr; 8(2):115-21. Review.	abstract
Antiviral applications of RNAi.	Morris K.V., and Rossi J.J. Handb Exp Pharmacol. 2006;(173):105-16	abstract
Inhibition of ocular angiogenesis by diced small interfering RNAs (siRNAs) specific to vascular endothelial growth factor (VEGF).	Murata, M., et al. Curr Eye Res. 2006 Feb;31(2):171-80.	abstract
An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection.	Palliser, D., et al. Nature. 2006 Jan 5;439(7072):89-94. Epub 2005 Nov 23.	abstract
RNA interference-mediated prevention and therapy for hepatocellular carcinoma.	Romano, P.R., et al. Oncogene. 2006. Jun 26; 25(27): 3857-65. Review.	abstract
Therapeutic potential of RNAi in metabolic diseases.	Rondinone, C.M. Biotechniques. 2006 Apr; Suppl:31-6. Review.	abstract
RNAi as a treatment for HIV-1 infection.	Rossi, J.J. Biotechniques. 2006 Apr; Suppl:25-9. Review.	abstract
A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium.	Santel, A., et al. Gene Ther. 2006 Aug;13(16):1222-34. Epub 2006 Apr 20.	abstract
Efficacy of siRNA nanocapsules targeted against the EWS-Fli1 oncogene in Ewing sarcoma.	Toub, N., et al. Pharm Res. 2006 May;23(5):892-900. Epub 2006 May 2.	abstract
In vivo Gene Transfer into Adult Stem Cells in Unconditioned Mice by in Situ Delivery of a Lentiviral Vector.	Worsham, D.N., et al. Mol Ther. 2006. 14: 514-24.	abstract
RNAi-mediated gene silencing in non-human primates.	Zimmermann, T.S., et al. Nature. 2006 May 4;441(7089):111-4. Epub 2006 Mar 26.	abstract
RNAi-induced gene silencing by local electroporation in targeting brain region.	Akaneya, Y., et al. J Neurophysiol. 2005 Jan;93(1):594-602.	abstract
RNAi as an antiviral therapy.	Bagasra, O. Expert Opin Biol Ther. 2005 Nov;5(11):1463-74. Review.	abstract
Use of RNA interference to prevent lethal murine west nile virus infection.	Bai, F., et al. J Infect Dis. 2005 Apr 1;191(7):1148-54. Epub 2005 Feb 23.	abstract
Inhibition of respiratory viruses by nasally administered siRNA.	Bitko, V., et al. Nat Med. 2005 Jan;11(1):50-5. Epub 2004 Dec 26.	abstract
State-of-the-art modified RNAi compounds for therapeutics.	Carstea, E.D., et al. IDrugs. 2005 Aug;8(8):642-7.	abstract
Novel cationic cardiolipin analogue-based liposome for efficient DNA and small interfering RNA delivery in vitro and in vivo.	Chein, P.Y., et al. Cancer Gene Ther. 2005 Mar;12(3):321-8.	abstract
Silencing viruses by RNA interference.	Colboere-Garapin, F., et al. Microbes Infect. 2005 Apr;7(4):767-75.	abstract
Two functional epitopes of pigment epithelial-derived factor block angiogenesis and induce differentiation in prostate cancer.	Filleur, S., et al. Cancer Res. 2005 Jun 15;65(12):5144-52.	abstract
Delivering RNA interference to the mammalian brain.	Fountaine, T.M., et al. Curr Gene Ther. 2005 Aug;5(4):399-410.	abstract
RNA interference & inhibition of viruses.	Gadkari, D.A. Indian J Med Res. 2005 Mar;121(3):147-50.	abstract
A small interfering RNA targeting vascular endothelial growth factor inhibits Ewing's sarcoma growth in a xenograft mouse model.	Guan, H., et al. Clin Cancer Res. 2005 Apr 1;11(7):2662-9.	abstract
Small interfering RNA-mediated functional silencing of vasopressin V2 receptors in the mouse kidney.	Hassan, A., et al. Physiol Genomics. 2005 May 11;21(3):382-8. Epub 2005 Mar 22.	abstract
RNA interference for treating haematological malignancies.	Hexner, E.O., and Gewirtz, A.M. Expert Opin Biol Ther. 2005 Dec;5(12):1585-92. Review.	abstract
Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma.	Hu-Lieskovan, S., et al. Cancer Research. 2005, 65, 8984-92.	abstract
Rad51 siRNA delivered by HVJ envelope vector enhances the anti-cancer effect of cisplatin.	Ito, M., et al. J Gene Med. 2005 Aug;7(8):1044-52.	abstract
Modification of professional antigen-presenting cells with small interfering RNA in vivo to enhance cancer vaccine potency.	Kim, T.W., et al. Cancer Res. 2005 Jan 1;65(1):309-16.	abstract
Potential applications of RNA interference technology in the treatment of cancer.	Lage, H. Future Oncol. 2005 Feb;1(1):103-13. Review.	abstract
Small interfering RNA targeting Raf-1 inhibits tumor growth in vitro and in vivo.	Leng, Q., et al. Cancer Gene Ther. 2005 Aug;12(8):682-90.	abstract
Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque.	Li, B.J., et al. Nature Medicine. 2005,9, 944-951.	abstract
Silencing of CXCR4 blocks breast cancer metastasis.	Liang, Z., et al. Cancer Res. 2005 Feb 1;65(3):967-71.	abstract
Down-regulation of apoptosis mediators by RNAi inhibits axotomy-induced retinal ganglion cell death in vivo.	Lingor, P., et al. Brain. 2005 Mar;128(Pt 3):550-8. Epub 2005 Jan 19.	abstract
Divergent roles of murine neutrophil chemokines in hemorrhage induced priming for acute lung injury.	Lomas-Neira, J., et al. Cytokine. 2005 Aug 7;31(3):169-79.	abstract
In vivo application of RNA interference: from functional genomics to therapeutics.	Lu, P.Y., et al. Adv Genet. 2005;54:117-42.	abstract
An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons.	Luo, M.C., et al. Mol Pain. 2005 Sep 28;1:29.	abstract
In vitro and in vivo suppression of GJB2 expression by RNA interference.	Maeda, Y., et al. Hum Mol Genet. 2005 Jun 15;14(12):1641-50. Epub 2005 Apr 27.	abstract
Targeting 2A protease by RNA interference attenuates coxsackieviral cytopathogenicity and promotes survival in highly susceptible mice.	Merl, S., et al. Circulation. 2005 Apr 5;111(13):1583-92. Epub 2005 Mar 28.	abstract
Stable inhibition of hepatitis B virus proteins by small interfering RNA expressed from viral vectors.	Moore, M., et al. J Gene Med. 2005 Jul;7(7):918-25.	abstract
Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs.	Morrissey, D.V., et al. Nat Biotechnol. 2005 Aug;23(8):1002-7. Epub 2005 Jul 24.	abstract
Intravesical administration of small interfering RNA targeting PLK-1 successfully prevents the growth of bladder cancer.	Nogawa, M., et al. J Clin Invest. 2005 Apr;115(4):978-85. Epub 2005 Mar 10.	abstract
Variants of bcl-2 specific siRNA for silencing antiapoptotic bcl-2 in pancreatic cancer.	Ocker, M., et al. Gut. 2005 Sep;54(9):1298-308.	abstract
Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer.	Pal, A., et al. Int J Oncol. 2005 Apr;26(4):1087-91.	abstract
Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo.	Pillé, J.Y., et al. Mol Ther. 2005 Feb;11(2):267-74.	abstract
Progress toward the therapy of hepatitis with RNAi.	Rendall, G. Hepatology. 2005 Jun;41(6):1220-2.	abstract
Gene silencing in rat-liver and limb grafts by rapid injection of small interference RNA.	Sato, Y., et al. Transplantation. 2005 Jan 27;79(2):240-3.	abstract
Effects of treatment with small interfering RNA on joint inflammation in mice with collagen-induced arthritis.	Schiffelers, R.M., et al. Arthritis Rheum. 2005 Apr;52(4):1314-8.	abstract
Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors.	Sharma, A., et al. Cancer Res. 2005 Mar 15;65(6):2412-21.	abstract
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors.	Song, E., et al. Nat Biotechnol. 2005 Jun;23(6):709-17. Epub 2005 May 22.	abstract
RNA interference-based gene silencing in mice: the development of a novel therapeutical strategy.	Spänkuch, B., et al. Curr Pharm Des. 2005;11(26):3405-19.	abstract
Exploring RNA interference as a therapeutic strategy for renal disease.	Takabatake, Y., et al. Gene Ther. 2005 Jun;12(12):965-73.	abstract
Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo.	Takeshita, F., et al. Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12177-82. Epub 2005 Aug 9.	abstract
Gene knockdown with intrathecal siRNA of NMDA receptor NR2B subunit reduces formalin-induced nociception in the rat.	Tan, P.H., et al. Gene Therapy. 2005, 12, 59-66.	abstract
siRNA-mediated knockdown of the serotonin transporter in the adult mouse brain.	Thakker, D.R., et al. Mol Psychiatry. 2005 Aug;10(8):782-9, 714.	abstract
Clearance of hepatitis B virus from the liver of transgenic mice by short hairpin RNAs.	Uprichard, S., et al. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):773-8.	abstract
RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo.	Urban-Klein, B., et al. Gene Ther. 2005 Mar;12(5):461-6.	abstract
Biology calls the targets: combining RNAi and disease biology.	van Es H.H., and Arts, G.J. Drug Discov Today. 2005 Oct 15;10(20):1385-91. Review.	abstract
Clinico-pathological rescue of a model mouse of Huntington's disease by siRNA.	Wang, Y.L., et al. Neurosci Res. 2005 Nov;53(3):241-9. Epub 2005 Aug 10.	abstract
In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice.	Wesche-Soldato, D.E., et al. Blood. 2005 Oct 1;106(7):2295-301. Epub 2005 Jun 7.	abstract
EphB4 expression and biological significance in prostate cancer.	Xia, G., et al. Cancer Res. 2005 Jun 1;65(11):4623-32.	abstract
Colony-stimulating factor-1 blockade by antisense oligonucleotides and small interfering RNAs suppresses growth of human mammary tumor xenografts in mice.	Aharinejad, S., et al. Cancer Res. 2004 Aug 1;64(15):5378-84.	abstract
RNA interference as a potential tool in the treatment of leukaemia.	Borkhardt, A., and Heidenreich, O. Expert Opin Biol Ther. 2004 Dec;4(12):1921-9.	abstract
Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference.	Chae, S.S., et al. J Clin Invest. 2004 Oct;114(8):1082-9.	abstract
Caspase-8 and caspase-3 small interfering RNA decreases ischemia/reperfusion injury to the liver in mice.	Contreras, J.L., et al. Surgery. 2004 Aug;136(2):390-400.	abstract
siRNA relieves chronic neuropathic pain.	Dorn, G., et al. Nucleic Acids Res. 2004 Mar 16;32(5):e49.	abstract
EphA2: a determinant of malignant cellular behavior and a potential therapeutic target in pancreatic adenocarcinoma.	Duxbury, M.S., et al. Oncogene. 2004 Feb 19;23(7):1448-56.	abstract
Systemic siRNA-mediated gene silencing: a new approach to targeted therapy of cancer.	Duxbury, M.S., et al. Ann Surg. 2004 Oct;240(4):667-74; discussion 675-6.	abstract
Efficient delivery of small interfering RNA for inhibition of IL-12p40 expression in vivo.	Flynn, M.A., et al. J Inflamm (Lond). 2004 Oct 1;1(1):4.	abstract
Inhibition of influenza virus production in virus-infected mice by RNA interference.	Ge, Q., et al. Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8676-81. Epub 2004 Jun 1.	abstract
Inhibition of gene expression in mice muscle by in vivo electrically mediated siRNA delivery.	Golzio, M., et al. Gene Therapy. 2004, 12, 246-251.	abstract
A facile nonviral method for delivering genes and siRNAs to skeletal muscle of mammalian limbs.	Hagstrom, J.E., et al. Molecular Therapy. 2004, 10, 386-398.	abstract
Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury.	Hamar, P., et al. Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14883-8. Epub 2004 Oct 4.	abstract
Lack of interferon response in animals to naked siRNAs.	Heidel, J., et al. Nature Biotechnology. 2004, 22, 1579-1582	abstract
Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: therapeutic strategy for herpetic stromal keratitis.	Kim, B., et al. Am J Pathol. 2004 Dec;165(6):2177-85.	abstract
Inhibition of synapse assembly in mammalian muscle in vivo by RNA interference.	Kong, X.C., et al. EMBO Report. 2004, 5, 183-188.	abstract
In vivo activity of nuclease-resistant siRNAs.	Layzer, J.M., et al. RNA. 2004, 10, 766-771.	abstract
Noninvasive delivery of small inhibitory RNA and other reagents to pulmonary alveoli in mice.	Massaro, D., et al. Am. J. Physiol. Lung. Cell. Mol. Physiol. 2004, 287, L1066-L1070.	abstract
Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo.	Minakuchi, Y., et al. Nucleic Acids Res. 2004 Jul 22;32(13):e109.	abstract
RNA interference targeting transforming growth factor-beta type II receptor suppresses ocular inflammation and fibrosis.	Nakamura, H., et al. Mol Vis. 2004 Oct 4;10:703-11.	abstract
Challenges for RNAi in vivo.	Paroo, Z., and Corey, D.R. Trends Biotechnol. 2004 Aug;22(8):390-4.	abstract
RNAi knock-down mice: an emerging technology for post-genomic functional genetics.	Prawitt, D., et al. Cytogenet Genome Res. 2004;105(2-4):412-21.	abstract
Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle.	Schiffelers, R.M., et al. Nucleic Acids Res. 2004 Nov 1;32(19):e149.	abstract
Systemic delivery of synthetic siRNAs.	Sioud, M., and Sørensen, D.R. Methods Mol Biol. 2004;252:515-22.	abstract
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs.	Soutschek, J., et al. Nature. 2004 Nov 11;432(7014):173-8.	abstract
Cancer inhibition in nude mice after systemic application of U6 promoter-driven short hairpin RNAs against PLK1.	Spänkuch, B., et al. J Natl Cancer Inst. 2004 Jun 2;96(11):862-72.	abstract
A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics.	Takei, Y., et al. Cancer Res. 2004 May 15;64(10):3365-70.	abstract
RNAi, a new therapeutic strategy against viral infection.	Tan, F.L., and Yin, J.Q. Cell Res. 2004 Dec;14(6):460-6.	abstract
Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference.	Thakker, D.R., et al. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17270-5. Epub 2004 Nov 29.	abstract
Intravitreal injection of vascular endothelial growth factor small interfering RNA inhibits growth and leakage in a nonhuman primate, laser-induced model of choroidal neovascularization.	Tolentino, M.J., et al. Retina. 2004, 24, 132-138.	abstract
Protection against lethal influenza virus challenge by RNA interference in vivo.	Tompkins, S.M., et al. Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8682-6. Epub 2004 Jun 1.	abstract
Antitumor activity of small interfering RNA/cationic liposome complex in mouse models of cancer.	Yano, J., et al. Clin Cancer Res. 2004 Nov 15;10(22):7721-6.	abstract
Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis.	Zhang, X., et al. J Biol Chem. 2004 Mar 12;279(11):10677-84. Epub 2003 Dec 18.	abstract
RNA interference targeting focal adhesion kinase enhances pancreatic adenocarcinoma gemcitabine chemosensitivity.	Duxbury, M.S., et al. Biochem Biophys Res Commun. 2003 Nov 21;311(3):786-92.	abstract
SiRNA-mediated inhibition of vascular endothelial growth factor severely limits tumor resistance to antiangiogenic thrombospondin-1 and slows tumor vascularization and growth.	Filleur, S., et al. Cancer Research. 2003, 63, 3919-3922.	abstract
Small interfering RNA inhibits hepatitis B virus replication in mice.	Giladi, H., et al. Mol Ther. 2003 Nov;8(5):769-76.	abstract
Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA.	Klein, C., et al. Gastroenterology. 2003 Jul;125(1):9-18.	abstract
Inhibition of Hepatitis B virus in mice by RNA interference.	McCaffrey, A.P., et al. Nature Biotechnology. 2003, 21, 639-644.	abstract
Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model.	Reich, S.J., et al. Mol Vis. 2003 May 30;9:210-6.	abstract
RNA interference targeting Fas protects mice from fulminant hepatitis.	Song, E., et al. Nat Med. 2003 Mar;9(3):347-51. Epub 2003 Feb 10.	abstract
Gene silencing by systemic delivery of synthetic siRNAs in adult mice.	Sørensen, D.R., et al. J Mol Biol. 2003 Apr 4;327(4):761-6.	abstract
Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells.	Verma, U.N., et al. Clin Cancer Res. 2003 Apr;9(4):1291-300.	abstract
Caspase 8 small interfering RNA prevents acute liver failure in mice.	Zender, L., et al. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7797-802. Epub 2003 Jun 16.	abstract
Phrenic long-term facilitation requires spinal serotonin receptor activation and protein synthesis.	Baker-Herman, T.L., et al. J Neurosci. 2002 Jul 15;22(14):6239-46.	abstract
Comparison of antisense oligonucleotides and siRNAs in cell culture and in vivo.	Bertrand, J.R., et al. Biochem Biophys Res Commun. 2002 Aug 30;296(4):1000-4.	abstract
Efficient delivery of siRNA for inhibition of gene expression in postnatal mice.	Lewis, D.L., et al. Nat Genet. 2002 Sep;32(1):107-8. Epub 2002 Jul 29.	abstract
Efficient delivery of siRNA for inhibition of gene expression in postnatal mice.	Lewis, D.L., et al. Nature Genetics. 2002, 21, 639-644.	abstract
Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake.	Makimura, H., et al. BMC Neurosci. 2002 Nov 7;3:18.	abstract
RNA interference in adult mice.	McCaffrey, A.P., et al. Nature. 2002 Jul 4;418(6893):38-9.	abstract

In Vivo Disease Treatment

Title	Author / Journal	Abstract
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.	Possemato R., et al. Nature.. 2011. Aug;476:346-350.	abstract
Control of mouse graft-versus-host disease following allogeneic bone marrow transplantation by blocking the CD28/B7 signaling pathway with lentiviral vector-mediated RNA interference.	Sang W., et al. Immunol Lett.. 2011. May;136(2):194-202. Epub 2011 Jan 26.	abstract
Therapeutic regulation of gene expression in the inner ear using RNA interference.	Maeda Y., et al. Adv. Otorhinolaryngol.. 2009;66:13-36. Epub 2009 Jun 2. Review.	abstract
Silencing the breast cancer resistance protein expression and function in caco-2 cells using lentiviral vector-based short hairpin RNA.	Zhang W., et al. Drug Metab. Dispos.. 2009 Apr;37(4):737-44. Epub 2009 Jan 8.	abstract
Targets of small interfering RNA restriction during human immunodeficiency virus type 1 replication.	Gao Y., et al. J. Virol.. 2008 Mar;82(6):2938-51. Epub 2008 Jan 16.	abstract
RNAi-mediated gene silencing in tumour tissue using replication-competent retroviral vectors.	Schaser T., et al. Gene Ther.. 2011. Apr 7. [Epub ahead of print]	abstract
Safety and Efficacy of a Lentiviral Vector Containing Three Anti-HIV Genes-CCR5 Ribozyme, Tat-rev siRNA, and TAR Decoy-in SCID-hu Mouse-Derived T Cells.	Anderson J, Li MJ, Palmer B, Remling L, Li S, Yam P, Yee JK, Rossi J, Zaia J, Akkina R. Mol Ther. 2007. Apr 3.	abstract
Lentiviral vector-mediated genetic modification of human neural progenitor cells for ex vivo gene therapy.	Capowski EE, Schneider BL, Ebert AD, Seehus CR, Szulc J, Zufferey R, Aebischer P, Svendsen CN. J Neurosci Methods. 2007. Mar 3.	abstract
Targeted transgene expression in muller glia of normal and diseased retinas using lentiviral vectors.	Greenberg KP, et al. Invest Ophthalmol Vis Sci. 2007. Apr;48(4):1844-52.	abstract
Target validation using RNA interference in solid tumors.	Aharinejad S, et al. Methods Mol Biol. 2007;361:227-38. Review.	abstract
Gene delivery to airway epithelial cells in vivo: a direct comparison of apical and basolateral transduction strategies using pseudotyped lentivirus vectors.	Kremer KL, et al. J Gene Med. 2007. Mar 22.	abstract
RNAi therapy for neurodegenerative diseases.	Boudreau RL, Davidson BL Curr Top Dev Biol. 2006. 75: 73-92. Review.	abstract
Interference RNA technology in the treatment of CNV.	Tolentino M Ophthalmol Clin North Am. 2006. Sep; 19(3): 393-9, vi-vii. Review.	abstract
RNA interference: a potential revolution in disease therapy.	Waseem T. J Coll Physicians Surg Pak. 2006. Jul; 16(7): 491-2. Review.	abstract
Correction of Cardiac Abnormalities in Fabry Mice by Direct Intraventricular Injection of a Recombinant Lentiviral Vector that Engineers Expression of alpha-Galactosidase A.	Yoshimitsu M, Higuchi K, Dawood F, Rasaiah VI, Ayach B, Chen M, Liu P, Medin JA. Circ J. 2006. Nov; 70(11): 1503-8.	abstract

MISSION^® siRNA Publications

Title	Author / Journal	Abstract
RNAi-Based Screening Identifies Kinases Interfering with Dioxin-Mediated Up-Regulation of CYP1A1 Activity	Gilot, D. et al. PLoS ONE 2011, 6(3).	e18261
Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts	Meng, W. et al. Cell 2008 Nov. 28, 135(5), 948-59.	abstract
BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation	Matsubara, T. et al. J. Biol. Chem. 2008 Oct., 283(43), 29119-25. Epub 2008 Aug, 14.	abstract
Genome-Scale RNAi Screen for Host Factors Required for HIV Replication	Zhou, H. et al. Cell Host Microbe 2008 Oct 29. [Epub ahead of print].	abstract
Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions.	Bartz. S.R., et al., Mol Cell Biol. 2006. 26: 9377-86.	abstract
Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival.	Chajès, V., et al., Cancer Res. 2006.66: 5287-94.	abstract
A genome wide analysis of ubiquitin ligases in APP processing identifies a novel regulator of BACE1 mRNA levels.	Espeseth, A.S., et al., Mol Cell Neurosci. 2006.33: 227-35.	abstract
Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation.	Kim, E.J., et al., J Biol Chem. 2006.281:33250-7.	abstract
Cleavage of the siRNA passenger strand during RISC assembly in human cells.	Leuschner, P.J., et al., EMBO Rep. 2006.7: 314-20.	abstract
A role for the Rab6A' GTPase in the inactivation of the Mad2-spindle checkpoint.	Miserey-Lenkei, S., et al., EMBO J. 2006.25: 278-89.	abstract
BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase.	Moreau, K., et al., J Biol Chem. 2006.281: 3172-81.	abstract
Cytopathic effects of the cytomegalovirus-encoded apoptosis inhibitory protein vMIA.	Poncet, D, et al., J Cell Biol. 2006.174: 985-96.	abstract
RalB mobilizes the exocyst to drive migration.	Rossé, C., et al., Mol Cell Biol. 2006.26: 727-34.	abstract
The assembly and maintenance of heterochromatin initiated by transgene repeats are independent of the RNA interference pathway in mammalian cells.	Wang, F., et al., Mol Cell Biol. 2006. 26: 4028-40.	abstract
Induction of centrosome amplification during arsenite-induced mitotic arrest in CGL-2 cells.	Yih, L.H., et al., Cancer Res. 2006.66: 2098-106.	abstract
A role for mammalian diaphanous-related formins in complement receptor (CR3)-mediated phagocytosis in macrophages	Colucci-Guyon, E., et al., Curr Biol. 2005.15: 2007-12.	abstract
A vital role of tubulin-tyrosine-ligase for neuronal organization.	Erck, C., et al., Proc Natl Acad Sci U S A. 2005. 102:7853-8.	abstract
Cdc42 and Par6-PKCzeta regulate the spatially localized association of Dlg1 and APC to control cell polarization.	Etienne-Manneville, S., et al., J Cell Biol. 2005.170: 895-901.	abstract
Mitogenic effects of the up-regulation of minichromosome maintenance proteins in anaplastic thyroid carcinoma.	Guida, T., et al., J Clin Endocrinol Metab. 2005.90 (8):4703-9.	abstract
Simple, quantitative primer-extension PCR assay for direct monitoring of microRNAs and short-interfering RNAs.	Johnson. J., et al., RNA. 2005.11: 1737-44.	abstract
Interferons alpha and gamma induce p53-dependent and p53-independent apoptosis, respectively.	Porta, C., et al., Oncogene 2005.24: 605-15.	abstract
RNA interference against human papillomavirus oncogenes in cervical cancer cells results in increased sensitivity to cisplatin.	Putral, L.N., et al., Mol Pharmacol. 2005.68:1311-9.	abstract
Tunicamycin enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human prostate cancer cells.	Shiraishi, T., et al., Cancer Res. 2005.65: 6364-70.	abstract
Alpha-tocopheryl succinate inhibits malignant mesothelioma by disrupting the fibroblast growth factor autocrine loop: mechanism and the role of oxidative stress.	Stapelberg, M., et al., J Biol Chem. 2005.280: 25369-76.	abstract
Selective gene silencing of rat ATP-binding cassette G2 transporter in an in vitro blood-brain barrier model by short interfering RNA.	Terasaki, T., et al., J Neurochem. 2005. 93: 63-71.	abstract
Inhibition of retinoblastoma protein degradation by interaction with the serpin plasminogen activator inhibitor 2 via a novel consensus motif.	Darnell, G.A., et al., Mol Cell Biol. 2003.23: 6520-32.	abstract

Specific Applications

Title	Author / Journal	Abstract
Mpz gene suppression by shRNA increases Schwann cell apoptosis in vitro.	Lei L., et al. Neurol Sci.. 2010 Oct;31(5):603-8. Epub 2010 Jun 15.	abstract
A more efficient RNAi inducible system for tight regulation of gene expression in mammalian cells and xenograft animals.	Zhang J., et al. RNA. 2007 Aug;13(8):1375-83. Epub 2007 Jul 6.	abstract
Lentivirus-mediated RNA interference targeting enhancer of zeste homolog 2 inhibits hepatocellular carcinoma growth through down-regulation of stathmin.	Chen Y., et al. Hepatology. 2007 Jul;46(1):200-8. Erratum in: Hepatology. 2007 Oct;46(4):1314.	abstract
STAT3-targeting RNA interference inhibits pancreatic cancer angiogenesis in vitro and in vivo.	Huang C., et al. Int. J. Oncol. 2011 Jun;38(6):1637-44. doi: 10.3892/ijo.2011.1000. Epub 2011 Apr 8.	abstract
Lentiviral-mediated Smad4 RNAi promotes SMMC-7721 cell migration by regulation of MMP-2, VEGF and MAPK signaling.	Huang X., et al. Mol. Med. Report. 2010 Mar-Apr;3(2):295-9. doi: 10.3892/mmr_00000254	abstract
RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation.	Walsh N., et al. Cancer Lett. 2011 Apr 4. [Epub ahead of print]	abstract
Down-Regulation of TNF-Alpha by Small Interfering RNA Inhibits Particle-Induced Inflammation in vitro.	Qin C.Q., et al. Artif. Organs. 2011 Apr 19. doi: 10.1111/j.1525-1594.2010.01175.x. [Epub ahead of print]	abstract
Nicotine Induces Pro-inflammatory Response in Aortic Vascular Smooth Muscle Cells Through a NF?B/Osteopontin Amplification Loop-Dependent Pathway.	Wang Y., et al. Inflammation. 2011 Apr 15. [Epub ahead of print]	abstract
beta Cell cytoprotection using lentiviral vector-based iNOS-specific shRNA delivery.	McCabe C, O'Brien T. Biochem. Biophys. Res. Commun.. 2007 May 25;357(1):75-80. Epub 2007 Mar 28.	abstract
Trophoblast-specific gene manipulation using lentivirus-based vectors.	Georgiades P, et al. Biotechniques. 2007. Mar;42(3):317-8, 320, 322-5.	abstract
Suppression of PPAR{gamma} Attenuates Insulin-Stimulated Glucose Uptake by Affecting Both GLUT1 and GLUT4 in 3T3-L1 Adipocytes.	Liao W, et al. Am J Physiol Endocrinol Metab. . 2007. Mar 27	abstract
CKS1B, over expressed in aggressive disease, regulates multiple myeloma growth and survival through SKP2- and p27Kip1-dependent and independent mechanisms.	Zhan F, et al. Blood. 2007. Feb 15.	abstract
VEGF-induced heme oxygenase-1 confers cytoprotection from lethal hyperoxia in vivo	Siner JM, et al. FASEB J. 2007. Jan 30.	abstract
Regulating MHC expression for cellular therapeutics.	Figueiredo C, et al. Transfusion. 2007. Jan; 47(1):18-27.	abstract
Identification of cell-type-specific promoters within the brain using lentiviral vectors.	Chhatwal JP, et al. Gene Ther. 2007. Jan 18.	abstract
Lentiviral and Murine Retroviral Transduction of T Cells for Expression of Human CD40 Ligand.	Simon, C. Barry, J. Seppen, N. Ramesh, J.L. Foster, K. Seyama, H.D. Ochs, J.V. Garcia, W.R.A. Osborne Human Gene Therapy. 2000. Jan; 11; (2): 323-332.	abstract
Lentiviral manipulation of gene expression in human adult and embryonic stem cells.	Clements MO, Godfrey A, Crossley J, Wilson SJ, Takeuchi Y, Boshoff C. Tissue Eng. 2006. Jul; 12; (7): 1741-51.	abstract
RNA interference pinpoints regulators of cell size and the cell cycle.	Cully MJ, Leevers SJ Genome Biol. 2006. 7(5): 219. Epub 2006 May 30. Review	abstract
Building mammalian signalling pathways with RNAi screens.	Moffat J, Sabatini DM. Nat Rev Mol. Cell. Biol.. 2006 Mar;7(3):177-87. Review.	abstract
Lentivirus vector gene expression during ES cell-derived hematopoietic development in vitro.	Hamaguchi I, et al. J. Virology. (2000) Vol.74 pp.10778-10784.	abstract
Application of lentivirus-mediated RNAi in studying gene function in mammalian tooth development.	Song Y, et al. Dev. Dyn.. 2006 Apr 20;235(5):1347-1357	abstract
Inhibition of hepatitis B virus surface antigen expression by small hairpin RNA in vitro.	Yang ZG., Chen Z., Ni Q., Xu N., Shao JB., Yao HP. World J Gastroenterol. 2005 Jan 28;11(4):498-502	abstract
Inhibition of hepatitis B virus gene expression by single and dual small interfering RNA treatment.	Wu KL, Zhang X., Zhang J., Yang Y., Mu YX, Liu M., Lu L., Li, Y., Zhu Y., Wu J. Virus Res. 2005 Sep;112(1-2):100-7	abstract
Application of RNA interference to study stem cell function: current status and future perspectives.	Zou GM, Yoder MC. Biol Cell. 2005 Mar;97(3):211-9	abstract
Exploiting the RNA interference pathway to counter hepatitis B virus replication.	Arbuthnot P., Carmona S., Ely A. Liver Int. 2005 Feb;25(1):9-15	abstract

Assay Design

Title	Author / Journal	Abstract
Mammalian RNAi: a practical guide.	Sandy P, Ventura A, Jacks T. Biotechniques. 2005 Aug;39(2):215-24	abstract
RNAi: the nuts and bolts of the RISC machine.	Filipowicz W. Cell. 2005 Jul 15;122(1):17-20	abstract
The best control for the specificity of RNAi.	Sarov M, Stewart AF. Trends Biotechnol. 2005 Sep;23(9):446-8	abstract
Detection of foreign RNA: implications for RNAi.	de Veer MJ, Sledz CA, Williams BR. Immunol Cell Biol. 2005 Jun;83(3):224-8	abstract
Defining and assaying RNAi in mammalian cells.	Huppi K, Martin SE, Caplen NJ. Mol. Cell. 2005 Jan 7;17(1):1-10	abstract

Reviews

Title	Author / Journal	Abstract
Role of RNA interference in plant improvement.	Jagtap U.B., et al. Naturwissenschaften. 2011 Apr 19. [Epub ahead of print]	abstract
RNAi-based therapeutic strategies for metabolic disease.	Czech M.P., et al. Nat. Rev. Endocrinol. 2011 Apr 19. [Epub ahead of print]	abstract
Current prospects for RNA interference-based therapies.	Davidson B.L., et al. Nat Rev Genet. 2011 May;12(5):329-40.	abstract
Getting RNAi therapies to the brain.	Flintoft L. Nat. Rev. Genet. 2011 May;12(5):296.	abstract
Strategies for silencing human disease using RNA interference.	Kim DH, et al. Curr Opin Oncol. 2007. Jan; 19(1): 50-4. Review.	abstract
RNA interference technologies and their use in Cancer Res.earch.	Gaither A, Iourgenko V. Curr Opin Oncol. 2007. Jan; 19(1): 50-4. Review.	abstract
Toxicity in mice expressing short hairpin RNAs gives new insight into RNAi.	Snove O Jr, Rossi JJ. Genome Biol. 2006; 7(8): 231. Review.	abstract
RNA interference in mice.	Kuhn R, Streif S, Wurst W. Handb Exp Pharmacol. 2007; 178: 149-76. Review.	abstract
RNA interference: natural, experimental, and clinical roles in cancer biology.	Mroz EA, Rocco JW. Head Neck. 2006; Dec; 28(12): 1132-41. Review.	abstract
Gene Silencing by Small Regulatory RNAs in Mammalian Cells.	Scherr M, Eder M. Cell Cycle. 2007; Feb 5; 6(4).	abstract
RNA Interference: A New Approach to in vivo Study of Gene Function.	Anthony RV, Cantlon JD. J Anim Sci. 2006. Oct; 13; [Epub ahead of print].	abstract
RNAi therapy for neurodegenerative diseases.	Boudreau RL, Davidson BL Curr Top Dev Biol. 2006. 75: 73-92. Review.	abstract
RNA interference: a potential revolution in disease therapy.	Waseem T. J Coll Physicians Surg Pak. 2006. Jul; 16(7): 491-2. Review.	abstract
RNA interference and potential applications	Zhou D, He QS, Wang C, Zhang J, Wong-Staal F. Curr Top Med Chem. 2006; 6(9): 901-11. Review	abstract
The RNA interference revolution	Lenz G. Braz J Med Biol Res. 2005 Dec; 38(12): 1749-57. Epub 2005 Nov 9. Review	abstract
Biology calls the targets: combining RNAi and disease biology.	van Es HH, Arts GJ. Drug Discov Today. 2005 Oct 15;10(20):1385-91	abstract
RNA interference in neuroscience: progress and challenges.	Miller VM, Paulson HL, Gonzalez-Alegre P. Cell Mol Neurobiol. 2005 Dec;25(8):1195-207. Review.	abstract
RNA interference & inhibition of viruses.	Gadkari DA. Indian J Med Res. 2005 Mar;121(3):147-50	abstract
RNAi versus small molecules: different mechanisms and specificities can lead to different outcomes.	Fitzgerald K. Curr Opin Drug Discov Devel. 2005 Sep;8(5):557-66	abstract
A Place for RNAi.	Anderson P. Dev Cell. 2005 Sep;9(3):311-2	abstract
Mammalian RNAi: a practical guide.	Sandy P, Ventura A, Jacks T. Biotechniques. 2005 Aug;39(2):215-24	abstract
Current efforts in the analysis of RNAi and RNAi target genes.	Bengert P, Dandekar T. Brief Bioinform. 2005 Mar;6(1):72-85	abstract
The ins and outs of RNAi in mammalian cells.	Banan M, Puri N. Curr Pharm Biotechnol. 2004 Oct;5(5):441-50	abstract
Approaches for chemically synthesized siRNA and vector-mediated RNAi.	Amarzguioui M, Rossi JJ KD. FEBS Lett. 2005 Oct 31;579(26):5974-81	abstract

High Titer

Title	Author / Journal	Abstract
On-target inhibition of tumor fermentative glycolysis as visualized by hyperpolarized pyruvate.	Seth P., et al. Neoplasia. Jan;13(1):60-71.	abstract
Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5.	Pavri R., et al. Cell. 2010 Oct 1;143(1):122-33.	abstract
Creating Higher Titer Lentivirus with Caffeine.	Ellis B., et al. Hum. Gene Ther. 2011 Jan;22(1):93-100. Epub 2010 Dec 12.	abstract

Screening

Title	Author / Journal	Abstract
Disease-Association Analysis of an Inflammation-Related Feedback Loop.	Murakami, M., et al. Cell Reports. 2013 Mar 28;3(3):946–959.	abstract
Functional identification of optimized RNAi triggers using a massively parallel sensor assay.	Fellmann C., et al. Mol. Cell.. 2011 Mar 18;41(6):733-46. Epub 2011 Feb 25.	abstract
Disturbance of the microRNA pathway by commonly used lentiviral shRNA libraries limits the application for screening host factors involved in hepatitis C virus infection.	Pan Q., et al. FEBS Lett. 2011 Apr 6;585(7):1025-30. Epub 2011 Mar 2.	abstract

General RNAi

Title	Author / Journal	Abstract
Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy.	Lister A., et al. Mol. Cancer. 2011 Apr 13;10(1):37. [Epub ahead of print]	abstract

RNAi in Neurons

Title	Author / Journal	Abstract
Opposing Roles of PlexinA and PlexinB in Axonal Branch and Varicosity Formation.	Neufeld S.Q., et al. Mol Brain. 2011 Apr 13;4(1):15. [Epub ahead of print]	abstract

RNAi in Yeast and Overview of RNAi Machinery

Title	Author / Journal	Abstract
Reconstitution of human RNA interference in budding yeast.	Sulk K., et al. Nucleic Acids Res. 2011 Apr 1;39(7):e43. Epub 2011 Jan 19.	abstract

In Vivo siRNA

Title	Author / Journal	Abstract
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes.	Alvarez-Erviti L., et al. Nat. Biotechnol. 2011 Apr;29(4):341-5. Epub 2011 Mar 20.	abstract

shRNA Transduction of Human Primary T Cells

Title	Author / Journal	Abstract
RNA Interference Screen in Primary Human T Cells Reveals FLT3 as a Modulator of IL-10 Levels	Astier A.L., et al. The Journal of Immunology. 2010 Jan;184(2):685-93. Epub 2009 Dec 16.	abstract
APOBEC3G-Depleted Resting CD4+ T Cells Remain Refractory to HIV1 Infection	Santoni de Sio F.R., et al. PLoS ONE. 2009 Aug;4(8):e6571.	abstract
Optimization and Functional Effects of Stable Short Hairpin RNA Expression in Primary Human Lymphocytes via Lentiviral Vectors	An D.S., et al. Molecular Therapy. 2006 Oct;14(4):494–504. Epub 2006 Jul 17.	abstract

Pooled shRNA Screening and Deconvolution

Title	Author / Journal	Abstract
RNAi screens in mice identify physiological regulators of oncogenic growth	Beronja S., et al. Nature. 2013 Aug 14. doi: 10.1038/nature12464. [Epub ahead of print]	abstract
Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK	Lin Y.Y., et al. Nature. 2012 Feb;482(7384):251–5.	abstract
A primer on using pooled shRNA libraries for functional genomic screens	Hu G., et al. Acta Biochim Biophys Sin. 2012 Feb;44(2):103–12.	abstract
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer	Possemato R., et al. Nature. 2011 Aug;476(7360):346-50.	abstract
Forward RNAi screens in human stem cells.	Karlsson, C., et al. Methods Mol. Biol. 2010; 650: 29-43.	abstract