- Highly enantioselective conjugate addition of nitromethane to chalcones using bifunctional cinchona organocatalysts.
Highly enantioselective conjugate addition of nitromethane to chalcones using bifunctional cinchona organocatalysts.
Organic letters (2005-05-07)
Benedek Vakulya, Szilárd Varga, Antal Csámpai, Tibor Soós
PMID15876031
ABSTRACT
Cinchona alkaloid-derived chiral bifunctional thiourea organocatalysts were synthesized and applied in the Michael addition between nitromethane and chalcones with high ee and chemical yields.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8a,9S)-10,11-dihydro-6′-methoxy-9-cinchonanyl]thiourea, 90%
Sigma-Aldrich
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8a,9S)-6′-methoxy-9-cinchonanyl]thiourea, 90%