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  • Paroxetine alleviates T lymphocyte activation and infiltration to joints of collagen-induced arthritis.

Paroxetine alleviates T lymphocyte activation and infiltration to joints of collagen-induced arthritis.

Scientific reports (2017-03-30)
Qingtong Wang, Longsheng Wang, Li Wu, Mei Zhang, Shanshan Hu, Rui Wang, Yongsheng Han, Yujing Wu, Lingling Zhang, Xinming Wang, Wuyi Sun, Wei Wei
PMID28349925
ABSTRACT

T cell infiltration to synovial tissue is an early pathogenic mechanism of rheumatoid arthritis (RA). In the present work, we reveal that G protein coupled receptor kinase 2 (GRK2) is abundantly expressed in T cells of collagen-induced arthritis (CIA). A GRK2 inhibitor, paroxetine protects the joints from inflammation and destruction, primarily through inhibition of both CD4