- A novel straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF.
A novel straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF.
Organic letters (2014-06-17)
Xiaowen Xu, Min Zhang, Huanfeng Jiang, Jia Zheng, Yiqun Li
PMID24933098
ABSTRACT
A novel straightforward synthesis of both symmetrical and unsymmetrical 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF as a one-carbon synthon has been developed. The presented method allows synthesizing the products that are currently inaccessible or challenging to prepare with the advantages of operational simplicity, broad substrate scope, and no need for prefunctionalized reagents, making it a highly practical approach to access various 2,4-disubstituted-1,3,5-triazines.
MATERIALS
Product Number
Brand
Product Description
Copper, IRMM®, certified reference material, 0.1 mm foil
Copper, tube, 100mm, outside diameter 0.25mm, inside diameter 0.05mm, wall thickness 0.1mm, as drawn, 99.9%
Copper, tube, 100mm, outside diameter 10.4mm, inside diameter 10mm, wall thickness 0.2mm, as drawn, 99.9%
Copper, tube, 1000mm, outside diameter 2.0mm, inside diameter 1.6mm, wall thickness 0.2mm, as drawn, 99.9%
Copper, tube, 1000mm, outside diameter 2.5mm, inside diameter 1.9mm, wall thickness 0.3mm, as drawn, 99.9%
Copper, sphere, 100pcs, diameter 1.0mm, precision sphere grade 200
Copper, tube, 100mm, outside diameter 0.65mm, inside diameter 0.21mm, wall thickness 0.22mm, as drawn, 99.9%
Copper, tube, 1000mm, outside diameter 0.25mm, inside diameter 0.05mm, wall thickness 0.1mm, as drawn, 99.9%
Copper, tube, 1000mm, outside diameter 3.5mm, inside diameter 1.56mm, wall thickness 0.97mm, as drawn, 99.9%
Copper, rod, 200mm, diameter 5.0mm, as drawn, 99.999%
Copper, rod, 100mm, diameter 12.7mm, as drawn, 99.99+%
Copper, tube, 1000mm, outside diameter 4.0mm, inside diameter 3.2mm, wall thickness 0.4mm, as drawn, 99.9%
Copper, rod, 200mm, diameter 6.35mm, as drawn, 99.999%
Copper, tube, 100mm, outside diameter 1.2mm, inside diameter 0.56mm, wall thickness 0.32mm, as drawn, 99.9%
Copper, rod, 50mm, diameter 16mm, as drawn, 99.99+%
Copper, rod, 500mm, diameter 8.0mm, as drawn, 99.99+%
Copper, tube, 1000mm, outside diameter 1.75mm, inside diameter 0.33mm, wall thickness 0.71mm, as drawn, 99.9%
Copper, rod, 50mm, diameter 5.0mm, as drawn, 99.999%
Copper, rod, 500mm, diameter 9.5mm, as drawn, 99.99+%
Copper, tube, 100mm, outside diameter 1.5mm, inside diameter 0.6mm, wall thickness 0.45mm, as drawn, 99.9%
Copper, tube, 1000mm, outside diameter 6.35mm, inside diameter 4.93mm, wall thickness 0.71mm, as drawn, 99.9%
Copper, rod, 500mm, diameter 9.5mm, hard, 99.9%
USP
Residual Solvent Class 2 - N,N-Dimethylformamide, United States Pharmacopeia (USP) Reference Standard
Copper - O.F.H.C., foil, 5m coil, thickness 0.025mm, hard, 99.95+%
Copper - O.F.H.C., foil, 25mm disks, thickness 0.25mm, annealed, 99.95+%
Copper - O.F.H.C., foil, 15mm disks, thickness 0.1mm, hard, 99.95+%
Copper - O.F.H.C., foil, 2m coil, thickness 0.006mm, hard, 99.95+%
Copper - O.F.H.C., foil, 50mm disks, thickness 0.1mm, hard, 99.95+%
Copper, wire reel, 1000m, diameter 0.1mm, annealed, 99.9%